Title:
POLYIONIC MICRO-SEALING
Document Type and Number:
Japanese Patent JPS6075326
Kind Code:
A
Abstract:
A process for damage-free encapsulation of a variety of core materials including viable cells involves suspending the core material in an aqueous solution of a polysaccharide containing cationic groups, such as an aminated glucopolysaccharide. A temporary matrix is formed by gelling droplets of the suspension using a solution containing a divalent or multivalent anion. The temporary matrix is permanently cross-linked with a polymeric material containing plural anionic groups, e.g., polyaspartic or polyglutamic acid, to form a semipermeable membrane. The interior of the microcapsule may be resolubilized by subjecting it to a solution of low molecular weight cations.
Inventors:
ARAN PII JIYAABISU JIYUNIA
Application Number:
JP18083184A
Publication Date:
April 27, 1985
Filing Date:
August 31, 1984
Export Citation:
Assignee:
DEIMON BAIOTEKU INC
International Classes:
A61K9/16; A61K9/50; B01J13/08; B01J13/14; B01J13/20; C07K14/00; C07K14/575; C07K16/00; C12N5/02; C12N11/04; (IPC1-7): B01J13/02; C07K15/00; C12N11/04
Domestic Patent References:
| JPS57197031A | 1982-12-03 |
Attorney, Agent or Firm:
Kyozo Yuasa
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