POLYMER CONJUGATE OF MUTATED NEUBLASTIN

Title:

POLYMER CONJUGATE OF MUTATED NEUBLASTIN

Document Type and Number:

Japanese Patent JP2010184924

Kind Code:

A

Abstract:

To identify a modified form of neublastin exhibiting prolonged bioavailability.

A dimer comprising a mutated neublastin polypeptide coupled to a polymer is provided. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. A pharmacological composition containing the dimer, a vector expressing a DNA encoding a nucleic acid (e.g. a polypeptide to be incorporated into the dimer), a host cell transformed with the nucleic acid, and a method for treating neuropathic pain in a mammal are provided.

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Inventors:

SAH DINAH WEN-YEE
BLAKE R PEPINSKY
BORIACK-SJODIN PAULA ANN
MILLER STEPHAN S
ROSSOMANDO ANTHONY
SILVIAN LAURA

Application Number:

JP2010069011A

Publication Date:

August 26, 2010

Filing Date:

March 24, 2010

Export Citation:

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Assignee:

BIOGEN IDEC INC

International Classes:

C07K14/475; A61K6/00; A61K38/00; A61K38/18; A61K47/48; A61P25/00; A61P25/02; A61P25/04; A61P25/16; C07K14/00; C12N15/09; C12N15/12; C12N15/18; A61K39/00; C07K

Domestic Patent References:

JP4742025B2

2011-08-10

Foreign References:

WO2002060929A2

2002-08-08

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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