PURPOSE: To obtain the harmless, stable and new subject polymer capable of producing (acetyl)salicylic acid having pharmacodynamic effects by hydrolysis and controlling pharmacodynamic effects by hydrolytic conditions, etc., and capable of carrying out broad application as a medicinal material thereby.
CONSTITUTION: The objective polymer has units of formula I and units of formula II. This polymer is preferably obtained by polymerizing an acetylsalicylic acid vinyl ester using an azo-based initiator such as 2,2'-azobisisobutylonitrile in an amount of 0.01-1wt.% based on acetylsalicylic acid vinyl ester by a solution polymerization method using an organic solvent such as methanol. Furthermore, the content of the unit I is preferably 0.1-99.3mol%. The control of acetylsalicylic acid group amount is preferably carried out by saponifying the polymer with NaOH, etc., in a mixed solvent of benzene and methanol.
SHIOMI TOMOO
IMAI KIYOKAZU
ONDA YOSHIRO
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