Title:
インビボでの酸化窒素送達用ポリマー
Document Type and Number:
Japanese Patent JP4846099
Kind Code:
B2
Abstract:
Disclosed are novel polymers derivatized with at least one -NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
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Inventors:
Stamlah, Jonathan, Es.
Toon, Eric, Jay.
Stack, Richard, S.
Toon, Eric, Jay.
Stack, Richard, S.
Application Number:
JP2000555946A
Publication Date:
December 28, 2011
Filing Date:
June 17, 1999
Export Citation:
Assignee:
Duke University Medical Center
International Classes:
A61L27/00; A61K31/785; C08G75/14; A61K47/48; A61L29/00; A61L31/10; A61L31/16; A61L33/00; A61L33/06; A61L33/08; C08B37/00; C08B37/16; C08G75/00
Domestic Patent References:
| JP6509323A | ||||
| JP6506222A |
Foreign References:
| WO1998005689A1 | 1998-02-12 | |||
| WO1996003139A1 | 1996-02-08 | |||
| WO1989012627A1 | 1989-12-28 |
Attorney, Agent or Firm:
Yoshinori Hosoda