POLYMERIZABLE BIODEGRADABLE POLYMERS INCLUDING CARBONATE OR DIOXANONE LINKAGES

Japanese Patent JP2014141509

A

PROBLEM TO BE SOLVED: To provide biodegradable and biocompatible macromers which can be rapidly polymerized in vivo to form hydrogels which are more elastic than conventional hydrogels.SOLUTION: Described are: water-soluble macromers including at least one hydrolyzable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group; and a method of preparation and use thereof. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at linkages within extension oligomers and results in fragments which are non-toxic and easily removed from a body.

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PETER K GIARETT
SAWHNEY AMARPREET
COURY ARTHUR J
RONALD S RUDOUSKI
POWELL MICHELLE D
AVILA LUIS Z
ENSCORE DAVID J
GOODRICH STEPHEN D
NASON WILLIAM C
YAO FEI
WEAVER DOUGLAS
BARMAN SHIKHA P

JP2014058500A

August 07, 2014

March 20, 2014

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GENZYME CORP

A61K9/16; A61K9/06; A61K9/50; A61L27/00; A61K9/70; A61K31/137; A61K31/404; A61K31/717; A61K31/722; A61K47/00; A61K47/34; A61L24/00; A61L24/04; A61L26/00; A61L31/06; A61L31/14; C08G63/64; C08G63/676; C08G65/00; C08G85/00

JPS63118326A

1988-05-23

JPN6008049536; ＳＡＷＨＮＥＹ，　Ａ．Ｓ．　ｅｔ　ａｌ．: Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ Ｖｏｌ．２６, 1993, ｐｐ．５８１-５８７

Hidesaku Yamamoto
Natsuki Morishita

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