POLYMORPHIC FORM A OF 4-[6-ACETYL-3-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENYLTHIO)PROPOXY]-2-PROPYLPHENOXY]BUTYRIC ACID

Title:

POLYMORPHIC FORM A OF 4-[6-ACETYL-3-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENYLTHIO)PROPOXY]-2-PROPYLPHENOXY]BUTYRIC ACID

Document Type and Number:

Japanese Patent JP2014097989

Kind Code:

A

Abstract:

To provide a novel crystalline form of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid, useful for allergic disease such as bronchial asthma.

In a pharmaceutical composition, at least about 90% of a compound of formula (1) is polymorphic form A, as defined by PXRD peak heights around 9° (2θ), and does not substantially contain other polymorphic forms, wherein the compound is particularly orthorhombic crystal.

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Inventors:

KENNETH WALTER LOCKE
ROE DAVID GREGORY

Application Number:

JP2013265114A

Publication Date:

May 29, 2014

Filing Date:

December 24, 2013

Export Citation:

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Assignee:

MEDICINOVA INC

International Classes:

A61K31/192; A61K9/20; A61K9/48; A61K47/26; A61K47/38; A61P11/06; A61P37/08; A61P43/00; C07C315/00; C07C323/22; C07C381/00; A61K

Domestic Patent References:

JPH0881412A	1996-03-26
JPH06345682A	1994-12-20
JPH021459A	1990-01-05

Other References:

橋田　充, 経口投与製剤の設計と評価, JPN6008031302, 10 February 1995 (1995-02-10), pages 76 - 79, ISSN: 0002983658

Attorney, Agent or Firm:

Tomijio Sasashima
Moriaki Ogawa
Haruyuki Nishiyama

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