Title:
POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME
Document Type and Number:
Japanese Patent JP2016188233
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods of preparing the same and use of the same.SOLUTION: Provided herein is a crystal form II of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, characterized in that the crystal form II exhibits a powder X-ray diffraction pattern obtained by using CuKradiation and having characteristic peaks expressed in degrees 2θ (±0.2° 2θ) at 5.899, 11.799, 14.481, 15.440, 18.420, 19.800 and 23.620 and in that the stoichiometric formula in an asymmetrical unit is determined as CHNO.HCl.(HO).SELECTED DRAWING: None
Inventors:
LI YOUXIN
LIU WANHUI
LV YANG
DU GUANHUA
MENG QINGGUO
YANG MINA
ZHOU FENGMEI
LI JU
ZHANG XUEMEI
LIU WANHUI
LV YANG
DU GUANHUA
MENG QINGGUO
YANG MINA
ZHOU FENGMEI
LI JU
ZHANG XUEMEI
Application Number:
JP2016124043A
Publication Date:
November 04, 2016
Filing Date:
June 23, 2016
Export Citation:
Assignee:
SHAN DONG LUYE PHARM CO LTD
LI YOUXIN
LI YOUXIN
International Classes:
C07C219/28; A61K31/235; A61P3/04; A61P13/10; A61P15/10; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/32; A61P25/36; C07C213/10
Domestic Patent References:
| JP2008543794A | 2008-12-04 |
Foreign References:
| WO2002046140A1 | 2002-06-13 |
Other References:
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塩路雄作, 固形製剤の製造技術, vol. 普及版第１刷, JPN6016031894, 27 January 2003 (2003-01-27), JP, pages 9 - 14, ISSN: 0004001811
平山令明 編著, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6016031902, 25 July 2008 (2008-07-25), JP, pages 37 - 84, ISSN: 0004001812
社団法人日本化学会 編, 第４版 実験化学講座１ 基本操作Ｉ, vol. 第２刷, JPN6016031896, 5 April 1996 (1996-04-05), JP, pages 184 - 186, ISSN: 0004001813
Attorney, Agent or Firm:
Katsuto Momii