Title:
POLYMORPHS OF ACYL SULFONAMIDES
Document Type and Number:
Japanese Patent JP2023082131
Kind Code:
A
Abstract:
To provide novel polymorphic crystalline forms of 2-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide sodium salt (Ib) with improved stability and physical properties which facilitate manufacturing, handling, and formulating for treatment or prophylaxis of HIV mediated diseases, AIDS or ARC, in monotherapy or in combination therapy.SOLUTION: The present invention provides nine polymorphic crystalline forms (I-IX) of a compound represented by formula Ib. There is also provided a process for preparing a crystalline form polymorph, comprising crystallizing the compound (Ib) from THF, water, and nBuAc.SELECTED DRAWING: None
Inventors:
MICHAEL MARTIN
JAMES PRENTICE DAVIDSON
PANG FEI
MARGARET WONG
JAMES PRENTICE DAVIDSON
PANG FEI
MARGARET WONG
Application Number:
JP2023057730A
Publication Date:
June 13, 2023
Filing Date:
March 31, 2023
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07C311/51; A61K9/02; A61K9/08; A61K9/10; A61K9/40; A61K9/48; A61K31/63; A61P31/18; C07C303/44
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni
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