Title:
ポリヌクレオチド療法
Document Type and Number:
Japanese Patent JP2005510533
Kind Code:
A
Abstract:
The invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), - polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
Inventors:
Fontura Paulo
Gallen Hideki
Robinson William H.
Stainman Lawrence
Louis Pedro Jose
Utsu Paul Jay.
Gallen Hideki
Robinson William H.
Stainman Lawrence
Louis Pedro Jose
Utsu Paul Jay.
Application Number:
JP2003546821A
Publication Date:
April 21, 2005
Filing Date:
November 21, 2002
Export Citation:
Assignee:
The Board of Trustees of Leland Stanford Junior University
International Classes:
C12N15/09; A61K38/20; A61K39/00; A61K48/00; A61P1/16; A61P3/04; A61P3/10; A61P19/00; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P37/00; (IPC1-7): A61K48/00; A61P1/16; A61P3/04; A61P3/10; A61P19/00; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P37/00
Foreign References:
| WO1999041369A2 | 1999-08-19 | |||
| WO2001006989A2 | 2001-02-01 | |||
| WO1999041383A1 | 1999-08-19 | |||
| WO1998055609A1 | 1998-12-10 | |||
| WO1999041369A2 | 1999-08-19 | |||
| WO2001006989A2 | 2001-02-01 | |||
| WO1999041383A1 | 1999-08-19 | |||
| WO1998055609A1 | 1998-12-10 |
Other References:
JPN7009000310; Ｒａｐｏｐｏｒｔ ＭＪ， Ｊａｒａｍｉｌｌｏ Ａ， Ｚｉｐｒｉｓ Ｄ， Ｌａｚａｒｕｓ ＡＨ， Ｓｅｒｒｅｚｅ ＤＶ， Ｌｅｉｔｅｒ ＥＨ， Ｃｙｏｐｉｃｋ Ｐ， Ｄａｎｓｋａ ＪＳ， Ｄｅｌｏｖｉｔ: 'Ｉｎｔｅｒｌｅｕｋｉｎ ４ ｒｅｖｅｒｓｅｓ Ｔ ｃｅｌｌ ｐｒｏｌｉｆｅｒａｔｉｖｅ ｕｎｒｅｓｐｏｎｓｉｖｅｎｅｓｓ ａｎｄ ｐｒｅｖｅｎｔｓ ｔｈｅ ｏｎｓｅｔ ｏｆ ｄｉａｂｅｔｅｓ ｉｎ ｎ' Ｊ Ｅｘｐ Ｍｅｄ． １７８（１）, 19930701, ８７-９９
JPN7009000311; Ｗｉｃｋｅｒ ＬＳ， Ｃｈｅｎ ＳＬ， Ｎｅｐｏｍ ＧＴ， Ｅｌｌｉｏｔｔ ＪＦ， Ｆｒｅｅｄ ＤＣ， Ｂａｎｓａｌ Ａ， Ｚｈｅｎｇ Ｓ， Ｈｅｒｍａｎ Ａ， Ｌｅｒｎｍａｒｋ Ａ， Ｚａｌｌｅｒ: 'Ｎａｔｕｒａｌｌｙ ｐｒｏｃｅｓｓｅｄ Ｔ ｃｅｌｌ ｅｐｉｔｏｐｅｓ ｆｒｏｍ ｈｕｍａｎ ｇｌｕｔａｍｉｃ ａｃｉｄ ｄｅｃａｒｂｏｘｙｌａｓｅ ｉｄｅｎｔｉｆｉｅｄ ｕｓｉｎｇ ｍｉｃｅ ｔｒａ' Ｊ Ｃｌｉｎ Ｉｎｖｅｓｔ． ９８（１１）, 19961201, ２５９７-２６０３
JPN7009000308; Ｊｉｎｄａｌ ＲＭ， Ｋａｒａｎａｍ Ｍ， Ｓｈａｈ Ｒ．: 'Ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｄｉａｂｅｔｅｓ ｉｎ ｔｈｅ ＮＯＤ ｍｏｕｓｅ ｂｙ ｉｎｔｒａ-ｍｕｓｃｕｌａｒ ｉｎｊｅｃｔｉｏｎ ｏｆ ｒｅｃｏｍｂｉｎａｎｔ ａｄｅｎｏ-ａｓｓｏｃｉａｔｅｄ' Ｉｎｔ Ｊ Ｅｘｐ Ｄｉａｂｅｔｅｓ Ｒｅｓ． ２（２）, 2001, １２９-１３８
JPN7009000309; Ｕｒｂａｎｅｋ-Ｒｕｉｚ Ｉ， Ｒｕｉｚ ＰＪ， Ｐａｒａｇａｓ Ｖ， Ｇａｒｒｅｎ Ｈ， Ｓｔｅｉｎｍａｎ Ｌ， Ｆａｔｈｍａｎ ＣＧ．: 'Ｉｍｍｕｎｉｚａｔｉｏｎ ｗｉｔｈ ＤＮＡ ｅｎｃｏｄｉｎｇ ａｎ ｉｍｍｕｎｏｄｏｍｉｎａｎｔ ｐｅｐｔｉｄｅ ｏｆ ｉｎｓｕｌｉｎ ｐｒｅｖｅｎｔｓ ｄｉａｂｅｔｅｓ ｉｎ ＮＯＤ ｍｉｃｅ' Ｃｌｉｎ Ｉｍｍｕｎｏｌ． １００（２）, 200108, １６４-１７１
JPN7010000637; ｖｏｎ Ｈｅｒｒａｔｈ ＭＧ， Ｗｈｉｔｔｏｎ ＪＬ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｔｏ ｔｒｅａｔ ａｕｔｏｉｍｍｕｎｅ ｄｉａｂｅｔｅｓ' Ａｎｎ Ｍｅｄ Ｖｏｌ．３２， Ｎｏ．５, 2000, ｐ．２８５-９２
JPN7009000308; Ｊｉｎｄａｌ ＲＭ， Ｋａｒａｎａｍ Ｍ， Ｓｈａｈ Ｒ．: 'Ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｄｉａｂｅｔｅｓ ｉｎ ｔｈｅ ＮＯＤ ｍｏｕｓｅ ｂｙ ｉｎｔｒａ-ｍｕｓｃｕｌａｒ ｉｎｊｅｃｔｉｏｎ ｏｆ ｒｅｃｏｍｂｉｎａｎｔ ａｄｅｎｏ-ａｓｓｏｃｉａｔｅｄ' Ｉｎｔ Ｊ Ｅｘｐ Ｄｉａｂｅｔｅｓ Ｒｅｓ． ２（２）, 2001, １２９-１３８
JPN7009000309; Ｕｒｂａｎｅｋ-Ｒｕｉｚ Ｉ， Ｒｕｉｚ ＰＪ， Ｐａｒａｇａｓ Ｖ， Ｇａｒｒｅｎ Ｈ， Ｓｔｅｉｎｍａｎ Ｌ， Ｆａｔｈｍａｎ ＣＧ．: 'Ｉｍｍｕｎｉｚａｔｉｏｎ ｗｉｔｈ ＤＮＡ ｅｎｃｏｄｉｎｇ ａｎ ｉｍｍｕｎｏｄｏｍｉｎａｎｔ ｐｅｐｔｉｄｅ ｏｆ ｉｎｓｕｌｉｎ ｐｒｅｖｅｎｔｓ ｄｉａｂｅｔｅｓ ｉｎ ＮＯＤ ｍｉｃｅ' Ｃｌｉｎ Ｉｍｍｕｎｏｌ． １００（２）, 200108, １６４-１７１
JPN7010000637; ｖｏｎ Ｈｅｒｒａｔｈ ＭＧ， Ｗｈｉｔｔｏｎ ＪＬ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｔｏ ｔｒｅａｔ ａｕｔｏｉｍｍｕｎｅ ｄｉａｂｅｔｅｓ' Ａｎｎ Ｍｅｄ Ｖｏｌ．３２， Ｎｏ．５, 2000, ｐ．２８５-９２
JPN7009000311; Ｗｉｃｋｅｒ ＬＳ， Ｃｈｅｎ ＳＬ， Ｎｅｐｏｍ ＧＴ， Ｅｌｌｉｏｔｔ ＪＦ， Ｆｒｅｅｄ ＤＣ， Ｂａｎｓａｌ Ａ， Ｚｈｅｎｇ Ｓ， Ｈｅｒｍａｎ Ａ， Ｌｅｒｎｍａｒｋ Ａ， Ｚａｌｌｅｒ: 'Ｎａｔｕｒａｌｌｙ ｐｒｏｃｅｓｓｅｄ Ｔ ｃｅｌｌ ｅｐｉｔｏｐｅｓ ｆｒｏｍ ｈｕｍａｎ ｇｌｕｔａｍｉｃ ａｃｉｄ ｄｅｃａｒｂｏｘｙｌａｓｅ ｉｄｅｎｔｉｆｉｅｄ ｕｓｉｎｇ ｍｉｃｅ ｔｒａ' Ｊ Ｃｌｉｎ Ｉｎｖｅｓｔ． ９８（１１）, 19961201, ２５９７-２６０３
JPN7009000308; Ｊｉｎｄａｌ ＲＭ， Ｋａｒａｎａｍ Ｍ， Ｓｈａｈ Ｒ．: 'Ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｄｉａｂｅｔｅｓ ｉｎ ｔｈｅ ＮＯＤ ｍｏｕｓｅ ｂｙ ｉｎｔｒａ-ｍｕｓｃｕｌａｒ ｉｎｊｅｃｔｉｏｎ ｏｆ ｒｅｃｏｍｂｉｎａｎｔ ａｄｅｎｏ-ａｓｓｏｃｉａｔｅｄ' Ｉｎｔ Ｊ Ｅｘｐ Ｄｉａｂｅｔｅｓ Ｒｅｓ． ２（２）, 2001, １２９-１３８
JPN7009000309; Ｕｒｂａｎｅｋ-Ｒｕｉｚ Ｉ， Ｒｕｉｚ ＰＪ， Ｐａｒａｇａｓ Ｖ， Ｇａｒｒｅｎ Ｈ， Ｓｔｅｉｎｍａｎ Ｌ， Ｆａｔｈｍａｎ ＣＧ．: 'Ｉｍｍｕｎｉｚａｔｉｏｎ ｗｉｔｈ ＤＮＡ ｅｎｃｏｄｉｎｇ ａｎ ｉｍｍｕｎｏｄｏｍｉｎａｎｔ ｐｅｐｔｉｄｅ ｏｆ ｉｎｓｕｌｉｎ ｐｒｅｖｅｎｔｓ ｄｉａｂｅｔｅｓ ｉｎ ＮＯＤ ｍｉｃｅ' Ｃｌｉｎ Ｉｍｍｕｎｏｌ． １００（２）, 200108, １６４-１７１
JPN7010000637; ｖｏｎ Ｈｅｒｒａｔｈ ＭＧ， Ｗｈｉｔｔｏｎ ＪＬ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｔｏ ｔｒｅａｔ ａｕｔｏｉｍｍｕｎｅ ｄｉａｂｅｔｅｓ' Ａｎｎ Ｍｅｄ Ｖｏｌ．３２， Ｎｏ．５, 2000, ｐ．２８５-９２
JPN7009000308; Ｊｉｎｄａｌ ＲＭ， Ｋａｒａｎａｍ Ｍ， Ｓｈａｈ Ｒ．: 'Ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｄｉａｂｅｔｅｓ ｉｎ ｔｈｅ ＮＯＤ ｍｏｕｓｅ ｂｙ ｉｎｔｒａ-ｍｕｓｃｕｌａｒ ｉｎｊｅｃｔｉｏｎ ｏｆ ｒｅｃｏｍｂｉｎａｎｔ ａｄｅｎｏ-ａｓｓｏｃｉａｔｅｄ' Ｉｎｔ Ｊ Ｅｘｐ Ｄｉａｂｅｔｅｓ Ｒｅｓ． ２（２）, 2001, １２９-１３８
JPN7009000309; Ｕｒｂａｎｅｋ-Ｒｕｉｚ Ｉ， Ｒｕｉｚ ＰＪ， Ｐａｒａｇａｓ Ｖ， Ｇａｒｒｅｎ Ｈ， Ｓｔｅｉｎｍａｎ Ｌ， Ｆａｔｈｍａｎ ＣＧ．: 'Ｉｍｍｕｎｉｚａｔｉｏｎ ｗｉｔｈ ＤＮＡ ｅｎｃｏｄｉｎｇ ａｎ ｉｍｍｕｎｏｄｏｍｉｎａｎｔ ｐｅｐｔｉｄｅ ｏｆ ｉｎｓｕｌｉｎ ｐｒｅｖｅｎｔｓ ｄｉａｂｅｔｅｓ ｉｎ ＮＯＤ ｍｉｃｅ' Ｃｌｉｎ Ｉｍｍｕｎｏｌ． １００（２）, 200108, １６４-１７１
JPN7010000637; ｖｏｎ Ｈｅｒｒａｔｈ ＭＧ， Ｗｈｉｔｔｏｎ ＪＬ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｔｏ ｔｒｅａｔ ａｕｔｏｉｍｍｕｎｅ ｄｉａｂｅｔｅｓ' Ａｎｎ Ｍｅｄ Ｖｏｌ．３２， Ｎｏ．５, 2000, ｐ．２８５-９２
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi