Title:
ポリペプチド-核酸コンジュゲートおよびその使用
Document Type and Number:
Japanese Patent JP2011505846
Kind Code:
A
Abstract:
The present invention is directed to polypeptide-nucleic acid conjugates. These conjugates can allow for targeted application of a therapeutic RNAi agent across the blood-brain barrier to treat, for example, a cancer, neurodegenerative disease, or lysosomal storage disorder.
Inventors:
Berivo, Richard
Michel demour
Che, Christian
Regina, Anthony
Michel demour
Che, Christian
Regina, Anthony
Application Number:
JP2010538304A
Publication Date:
March 03, 2011
Filing Date:
December 19, 2008
Export Citation:
Assignee:
Angiochem, Incorporated
International Classes:
C12N15/113; A61K31/337; A61K31/7105; A61K39/395; A61K45/00; A61K45/06; A61K47/42; A61K47/48; A61K48/00; A61P3/10; A61P9/10; A61P21/02; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P35/00; A61P35/04; C07K7/08; C07K14/00; C12N15/09
Domestic Patent References:
| JP2007526227A | 2007-09-13 | |||
| JP2007536253A | 2007-12-13 |
Foreign References:
| US20060189515A1 | 2006-08-24 | |||
| WO2006086870A1 | 2006-08-24 |
Other References:
JPN6013052942; Ｎａｔｕｒｅ， ２００７， Ｖｏｌ．４４８， Ｎｏ．７１４９， ｐ．３９-４３
JPN6013052943; Ｊ． Ｐｈａｒｍａｃｏｌ． Ｅｘｐ． Ｔｈｅｒ．， ２００８， Ｖｏｌ．３２４， Ｎｏ．３， ｐ．１０６４-１０７２
JPN6013052940; Ｃａｎｃｅｒ Ｒｅｓ．， ２００４， Ｖｏｌ．６４， ｐ．３３６５-３３７０
JPN6013052941; Ｇｅｎｅｔ． Ｖａｃｃｉｎｅｓ Ｔｈｅｒ．， ２００５， Ｖｏｌ．３， ｐ．５／１-１２
JPN6013052943; Ｊ． Ｐｈａｒｍａｃｏｌ． Ｅｘｐ． Ｔｈｅｒ．， ２００８， Ｖｏｌ．３２４， Ｎｏ．３， ｐ．１０６４-１０７２
JPN6013052940; Ｃａｎｃｅｒ Ｒｅｓ．， ２００４， Ｖｏｌ．６４， ｐ．３３６５-３３７０
JPN6013052941; Ｇｅｎｅｔ． Ｖａｃｃｉｎｅｓ Ｔｈｅｒ．， ２００５， Ｖｏｌ．３， ｐ．５／１-１２
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka