Title:
POLYPEPTIDE CONSTRUCT AND USE THEREOF
Document Type and Number:
Japanese Patent JP2017193580
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a polypeptide construct comprising a mutated, attenuated polypeptide ligand attached to an antibody, the antibody directing the mutated ligand to a cell that expresses on its surface the antigen to which the antibody bind, as well as a receptor for the ligand.SOLUTION: According to the present invention, there is provided a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen-binding portion thereof, which binds to a cell surface-associated antigen. Here, the ligand comprises at least one amino acid substitution or deletion, which reduces its potency on a cell lacking expression of the antigen.SELECTED DRAWING: None
More Like This:
Inventors:
DAVID S WILSON JR
SARAH L POGUE
GLEN E MIKESELL
TAURA TETSUYA
WOUTER KORVER
ANTHONY G DOYLE
ADAM CLARKE
MATTHEW POLLARD
STEPHEN TRAN
JACK TZU CHIAO LIN
SARAH L POGUE
GLEN E MIKESELL
TAURA TETSUYA
WOUTER KORVER
ANTHONY G DOYLE
ADAM CLARKE
MATTHEW POLLARD
STEPHEN TRAN
JACK TZU CHIAO LIN
Application Number:
JP2017144182A
Publication Date:
October 26, 2017
Filing Date:
July 26, 2017
Export Citation:
Assignee:
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD
International Classes:
C07K19/00; A61K38/20; A61K38/21; A61K39/395; A61P35/00; C07K14/54; C07K14/555; C07K14/56; C07K14/565; C07K14/57; C07K16/28; C07K16/30
Domestic Patent References:
| JP6184965B2 | 2017-08-23 | |||
| JP2010540453A | 2010-12-24 | |||
| JP2009501514A | 2009-01-22 | |||
| JP2020010697A | 2020-01-23 | |||
| JP2003535908A | 2003-12-02 |
Foreign References:
| WO2008124086A2 | 2008-10-16 | |||
| FR2905375A1 | 2008-03-07 | |||
| WO2013134138A1 | 2013-09-12 | |||
| WO2004022593A2 | 2004-03-18 | |||
| WO2004022747A1 | 2004-03-18 | |||
| US8124738B2 | 2012-02-28 |
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CASCAVILLA, N. ET AL., HAEMATOLOGICA, vol. 83, JPN6020006921, 1998, pages 392 - 397, ISSN: 0004224364
HIDEAKI KODAMA ET AL.: "Mutated SEA-D227A-conjugated antibodies greatly enhance antitumor activity against MUC1-expressing b", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 50, no. 10, JPN6016032192, 2001, pages 539 - 548, XP055148851, ISSN: 0003846479, DOI: 10.1007/s002620100219
HUANG, T.-H. ET AL., J. IMMUNOL., vol. 179, JPN6018029139, 2007, pages 6881 - 6888, ISSN: 0003846480
PAN, M. ET AL., BIOCHEMISTRY, vol. 47, JPN6018029144, 2008, pages 12018 - 12027, ISSN: 0003846482
STEWART, A.G. ET AL., DNA, vol. 6, no. 2, JPN6018029142, 1987, pages 119 - 128, ISSN: 0003846483
TRZPIS, M. ET AL., AM. J. PATHOL., vol. 171, no. 2, JPN6019010859, 2007, pages 386 - 395, ISSN: 0004004923
高橋利忠, 実験医学, vol. Vol.31, No.12(増刊), JPN6020038105, 2013, pages 21 - 29, ISSN: 0004361368
THOMAS, C. ET AL., CELL, vol. 146, JPN6018029134, 19 August 2011 (2011-08-19), pages 621 - 632, ISSN: 0003846476
JACOB PIEHLER ET AL.: "New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comp", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 51, JPN6016032193, 22 December 2000 (2000-12-22), pages 40425 - 40433, XP002267030, ISSN: 0003846477, DOI: 10.1074/jbc.M006854200
生物学辞典, vol. 第1版, 第1刷, JPN6018029138, 2010, pages 101, ISSN: 0003846478
生物学辞典, vol. 第1版, 第1刷, JPN6019010861, 2010, pages 28 - 29, ISSN: 0004004922
ZHU, J. ET AL., J. GASTROENTEROL. HEPATOL., vol. 26, no. 10, JPN6020006858, 9 May 2011 (2011-05-09), pages 1519 - 1526, ISSN: 0004224365
MERSMANN, M. ET AL., INT. J. CANCER, vol. 92, JPN6020006883, 2001, pages 240 - 248, ISSN: 0004224366
VERED, M. ET AL., INT. J. CANCER, vol. 127, JPN6020006888, 2010, pages 1356 - 1362, ISSN: 0004224367
KUWAI, T. ET AL., CLIN. EXP. METASTASIS, vol. 25, JPN6020006894, 2008, pages 477 - 489, ISSN: 0004224368
SHINAGAWA, K. ET AL., INT. J. CANNCER, vol. 127, JPN6020006895, 2010, pages 2323 - 2333, ISSN: 0004224369
FLEGEL, W.A., BLOOD TRANSFUS, vol. 5, JPN6020006899, 2007, pages 50 - 57, ISSN: 0004224370
BEARE, A. ET AL., CURR. PROTOC. IMMUNOL., vol. 80, JPN6020006908, 2008, pages 4 - 1, ISSN: 0004224371
XUAN, C. ET AL., BLOOD, vol. 115, no. 14, JPN6020006846, 2010, pages 2864 - 2871, ISSN: 0004224372
ROSSI, E.A. ET AL., BLOOD, vol. 114, no. 18, JPN6020006848, 2009, pages 3864 - 3871, ISSN: 0004224373
TAI, Y.-T. ET AL., BLOOD, vol. 112, JPN6020006854, 2008, pages 1329 - 1337, ISSN: 0004224374
JACKSON, D. ET AL., CANCER RES., vol. 52, JPN6020006860, 1992, pages 5264 - 5270, ISSN: 0004224375
HUANG, L.-R. AND HSU, H.-C., CANCER RES., vol. 55, JPN6020006863, 1995, pages 4717 - 4721, ISSN: 0004224376
PEARSON, J.W. ET AL., CANCER RES., vol. 50, JPN6020006866, 1990, pages 6379 - 6388, ISSN: 0004224377
CHANG, C.S. ET AL., BMC CANCER, vol. 7, JPN6020006869, 2007, pages 88 - 1, ISSN: 0004224378
HOSEN, N. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 104, no. 26, JPN6020006871, 2007, pages 11008 - 11013, ISSN: 0004224379
BASEGGIO, L. ET AL., MODERN PATHOLOGY, vol. 24, JPN6020006873, 15 April 2011 (2011-04-15), pages 993 - 1003, ISSN: 0004224380
SHIMAUCHI, T. ET AL., INT. J. CANCER, vol. 121, JPN6020006884, 2007, pages 2585 - 2590, ISSN: 0004224381
CHADBURN, A. ET AL., AM. J. PATHOL., vol. 136, no. 1, JPN6020006875, 1990, pages 29 - 37, ISSN: 0004224382
PINTO, A. ET AL., ANN. ONCOL., vol. Vol.2, Suppl.2, JPN6020006924, 1991, pages 107 - 113, ISSN: 0004224383
SMITH, H.O. ET AL., CLIN. CANCER RES., vol. Vo.1, JPN6020006886, 1995, pages 313 - 325, ISSN: 0004224384
PICCALUGA, P.P. ET AL., J. CLIN. INVEST., vol. 117, no. 3, JPN6020006897, 2007, pages 823 - 834, ISSN: 0004224385
KATO, Y. ET AL., J. BIOL. CHEM., vol. 278, no. 51, JPN6020006901, 2003, pages 51599 - 51605, ISSN: 0004224386
CHANG, T.-H. AND SZABO, E., CANCER RES., vol. 60, JPN6020006902, 2000, pages 1129 - 1138, ISSN: 0004224387
CHINNASAMY, D. ET AL., J. CLIN. INVEST., vol. 120, no. 11, JPN6020006904, 2010, pages 3953 - 3968, ISSN: 0004224388
HIGGINS, J.P. ET AL., CANCER BIOL. THER., vol. 8, no. 15, JPN6020006905, 2009, pages 1440 - 1449, ISSN: 0004224389
GREINER, J. ET AL., EXP. HEMATOL., vol. 30, JPN6020006909, 2002, pages 1029 - 1035, ISSN: 0004224390
ISHIGAMI, S. ET AL., BMC CANCER, vol. 11, JPN6020006916, 24 March 2011 (2011-03-24), pages 106 - 1, ISSN: 0004224391
HAYASHIDA, M. ET AL., CYTOMETRY RESEARCH, vol. 15, no. 2, JPN6020006918, 2005, pages 7 - 14, ISSN: 0004224392
KALIE, E. ET AL., J. BIOL. CHEM., vol. 282, no. 15, JPN6018029140, 2007, pages 11602 - 11611, ISSN: 0004224359
CAMPBELL, I.G. ET AL., CANCER RES., vol. 54, JPN6020006919, 1994, pages 5761 - 5765, ISSN: 0004224393
生化学辞典, vol. 第3版, JPN6020006849, 2002, pages 687 - 689, ISSN: 0004224360
GOLDMACHER, V.S. AND KOVTUN, Y.V., THER. DELIV., vol. 2, no. 3, JPN6020006851, 9 March 2011 (2011-03-09), pages 397 - 416, ISSN: 0004224361
TAI, Y.-T. AND ANDERSON, K.C., BONE MARROW RES., vol. 2011, JPN6020006852, 2 March 2011 (2011-03-02), pages 924058 - 1, ISSN: 0004224362
PELLAT-DECEUNYNCK, C. ET AL., CANCER RES., vol. 55, JPN6020006855, 1995, pages 3647 - 3653, ISSN: 0004224363
CASCAVILLA, N. ET AL., HAEMATOLOGICA, vol. 83, JPN6020006921, 1998, pages 392 - 397, ISSN: 0004224364
HIDEAKI KODAMA ET AL.: "Mutated SEA-D227A-conjugated antibodies greatly enhance antitumor activity against MUC1-expressing b", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 50, no. 10, JPN6016032192, 2001, pages 539 - 548, XP055148851, ISSN: 0003846479, DOI: 10.1007/s002620100219
HUANG, T.-H. ET AL., J. IMMUNOL., vol. 179, JPN6018029139, 2007, pages 6881 - 6888, ISSN: 0003846480
PAN, M. ET AL., BIOCHEMISTRY, vol. 47, JPN6018029144, 2008, pages 12018 - 12027, ISSN: 0003846482
STEWART, A.G. ET AL., DNA, vol. 6, no. 2, JPN6018029142, 1987, pages 119 - 128, ISSN: 0003846483
TRZPIS, M. ET AL., AM. J. PATHOL., vol. 171, no. 2, JPN6019010859, 2007, pages 386 - 395, ISSN: 0004004923
高橋利忠, 実験医学, vol. Vol.31, No.12(増刊), JPN6020038105, 2013, pages 21 - 29, ISSN: 0004361368
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe