POLYPEPTIDE HAVING PHOSPHODIESTERASE ACTIVITY

Title:

POLYPEPTIDE HAVING PHOSPHODIESTERASE ACTIVITY

Document Type and Number:

Japanese Patent JP2005229806

Kind Code:

A

Abstract:

To provide a new polypeptide having a PDE (phosphodiesterase) activity, a DNA encoding the PDE polypeptide and medicines for diagnosis, prophylaxis or therapy of diabetes, ischemic heart diseases, hypertension, nephritis, pancreatitis, ulcer, allergy, asthma, rheumatism, osteoporosis, pain, anxiety, schizophrenia, manic-depressive psychosis, Parkinson's disease, dementia, infectious diseases, malignant tumor, etc., by utilizing the DNA or an antibody recognizing the polypeptide.

The new polypeptide has the PDE activity. A method for producing the polypeptide and the DNA encoding the polypeptide are provided. A recombinant vector is obtained by integrating the DNA. A transformant carries the recombinant vector. The antibody recognizes the polypeptide. A method for determining the polypeptide and an immunostaining method use the antibody. A method for screening substances varying the expression of a gene encoding the polypeptide is provided. The medicines, etc., for diagnosis, prophylaxis or therapy of diseases such as diabetes, encephalopathy, renopathy or cancer using the DNA or antibody are provided.

Inventors:

MIYAJI HIROMASA
KANBE MOTOKO
OTA NORIO
KAWABATA AYAKO
SUGANO SUMIO
NAKAMURA YUSUKE

Application Number:

JP2000208610A

Publication Date:

September 02, 2005

Filing Date:

July 10, 2000

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KYOWA HAKKO KOGYO KK

International Classes:

G01N33/50; A61K31/7125; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P1/18; A61P3/10; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P19/10; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P37/08; C07K14/47; C07K16/40; C12N1/21; C12N9/16; C12N15/09; C12N15/12; C12N15/55; C12P21/02; C12P21/08; C12Q1/44; C12Q1/66; C12Q1/68; G01N33/15; G01N33/53; G01N33/573; G01N33/68; C12R1/19; (IPC1-7): C12N15/09; A61K31/7125; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P1/18; A61P3/10; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P19/10; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P37/08; C07K14/47; C07K16/40; C12N1/21; C12N9/16; C12P21/02; C12Q1/44; C12Q1/66; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/573; G01N33/68

Attorney, Agent or Firm:

Masazumi Imamura
Toshio Shiozawa
Junji Kamata

Previous Patent: METHOD FOR SIMULATING LIFE SCIENCE AND LIFE SCIENCE SIMULATOR

Next Patent: METHOD FOR PRODUCING TRANSGLUTAMINASE