POLYPEPTIDE ISOLATED FROM EPIDERMIS AND ITS USE

Japanese Patent JP3819603

B2

PROBLEM TO BE SOLVED: To obtain an isolated polypeptide belonging to a cysteine protease group of cathepsin L-type, having a specific apparent molecular weight and useful for reducing corneal cell conjugation and accelerating exfoliation.
SOLUTION: This isolated natural or synthesized polypeptide belongs to a cysteine protease group of cathepsin L-type and has 15-32 KDa, preferably 25-30 KDa apparent molecular weight and 6-9 isoelectric point, and is obtained by preferably isolating from a tissue of a mammal, especially the skin of a mammal, more preferably from the skin of a human, especially from the epidermis of the human. In using it to a pharmaceutical formulation, 0.00001-50%, preferably 0.001-10%, more preferably 0.1-1% of the polypeptide is included in the formulation.

Dominique bernard
Michelle Kermi
Mali-Alix Bernard-Bourblon

JP24405598A

September 13, 2006

August 28, 1998

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LOREAL

A61K8/06; A61K8/72; A61K8/34; A61K8/40; A61K8/41; A61K8/64; A61K8/66; A61K8/98; A61K38/46; A61P17/00; A61P35/00; A61Q19/00; C12N9/64; C12S3/14; A61K39/00; (IPC1-7): A61K7/00; A61K7/00; A61K38/46

Biochem.J.(1986)Vol.233,No.3,p.925-927
Biochemistry,(1993)Vol.32,No.1,p.375-380
Cancer Reserch,(1990)Vol.50,No.3,p.658-663
The Biochemical Journal,253(1)(1988),p.303-306
Archives of Dermatological Research,289(2)(1997),p.87-93

Sonoda Yoshitaka
Kobayashi Yoshinori

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