To provide a blood purifier adapted as an HDFIII-b type blood purifier presented as a guideline by Japanese Society for Dialysis Therapy, which is a dry type.
For the polysulfone-based hollow fiber membrane type blood purifier, while cow blood adjusted to hematocrit (Ht) 40±2.0% and total protein concentration 6.5±0.5 g/dl is made to flow at 300 ml/min and at a filtration speed 90 ml/min to the blood purifier (inner diameter reference membrane area 1.5 m2) filled with polysulfone-based permselective hollow fiber membrane bundle containing polyvinylpyrroliidone, when sieving coefficients of β2-microglobulin after 15 minutes and after 120 minutes after starting hemofiltration are respectively defined as SCβ2MG (15 minutes) and SCβ2MG (120 minutes), it is SCβ2MG (120 minutes)/SCβ2MG (15 minutes)≥0.6. When the hollow fiber membrane bundle is divided into 10 pieces in a longitudinal direction and when a test determined by standards of approval for the manufacture of hemodialysis apparatuses is performed for respective parts, the hydrogen peroxide elution amount of obtained extract is ≤5 ppm in all the parts.
KUZE KATSURO
MABUCHI KOYO
ONO HITOSHI
JPH09154936A | 1997-06-17 | |||
JP2004305840A | 2004-11-04 | |||
JPH07289866A | 1995-11-07 | |||
JPH11309353A | 1999-11-09 | |||
JPH09220455A | 1997-08-26 | |||
JPH10108907A | 1998-04-28 | |||
JP2003245526A | 2003-09-02 | |||
JP2005066389A | 2005-03-17 | |||
JP2000296318A | 2000-10-24 | |||
JPH09308684A | 1997-12-02 | |||
JP2005052362A | 2005-03-03 | |||
JP2005007004A | 2005-01-13 | |||
JP2001170171A | 2001-06-26 | |||
JPH10230148A | 1998-09-02 | |||
JP2001038172A | 2001-02-13 |
WO2004006991A1 | 2004-01-22 |