Title:
POLYSULFURIC ESTER OF SULFONAMIDE DERIVATIVE OF BETA-CYCLODEXTRIN AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JPH04136001
Kind Code:
A
Abstract:
PURPOSE:To prepare a medicinal compd. which effectively prevents the growth of a human immunodeficiency virus without showing side effect by reacting a specific sulfonamide deriv. of beta-cyclodextrin with a sulfonating agent. CONSTITUTION:A sulfonamide deriv. of beta-cyclodextrin wherein at least one of the seven D-glucose units constituting beta-cyclodextrin has been substd. by a unit of the formula is reacted with a sulfonating agent, and if necessary the reaction product is converted into a salt, giving a polysulfuric ester of the sulfonamide deriv. or a salt of the ester. In the formula, R<1> is alkyl, phenyl, naphthyl, or heterocyclic. The sulfonamide deriv. is a new compd. and prepd. by reacting beta-cyclodextrin with a substd. sulfonic acid halide, separating and purifying the reaction product if necessary, reacting it with ammonia, and sulfonamidating the resulting product by a suitable method.
Inventors:
KURITA HIROKI
MORIYA TAMON
OTAKE TORU
MORI HARUYO
MORIMOTO MOTOKO
MORIYA TAMON
OTAKE TORU
MORI HARUYO
MORIMOTO MOTOKO
Application Number:
JP25925790A
Publication Date:
May 11, 1992
Filing Date:
September 27, 1990
Export Citation:
Assignee:
TANABE SEIYAKU CO
International Classes:
C08B37/16; A61K31/715; A61P31/12; (IPC1-7): A61K31/735; C08B37/16
Attorney, Agent or Firm:
Shigeo Minoura
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