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Title:
POMOL ACID AND OLEANOL ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH0717995
Kind Code:
A
Abstract:

PURPOSE: To provide novel compounds having acceleration activity to produce prostaglandin I2, thrombolytic activity or the like and useful in the treatment and prevention of thrombosis or arteriosclerosis.

CONSTITUTION: This pomol acid or oleanol acid derivative of formula I (wherein R1 represents H or acetyl; a group of formula II is a group of formula III when R1 is H, and the group of formula II is a group of formula IV when R1 is acetyl), for example 3β-O-[α-L-(2'-acetyl)arabinopyranosyl]pomol acid (28→1)-β-D-glucopyranoxyl ester or the like is obtained, for example by extracting from dried crude drug of Aquifobaceae Ilex cornuta Lindl. in an polar solvent such as methanol, ethanol or the like.


Inventors:
Fukuyama, Yoshiyasu
Chiin, Wen Juen
Woo, Shuu A.
Chao, Chuin JE
Application Number:
JP1993000225368
Publication Date:
January 20, 1995
Filing Date:
September 10, 1993
Export Citation:
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Assignee:
OTSUKA PHARMACEUT CO LTD
PEITIN TUYOGON IEIENCHUUSUO
International Classes:
A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K36/18; A61P1/04; A61P1/16; A61P3/06; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P11/08; A61P43/00; C07H15/256; C07J17/00; (IPC1-7): C07J17/00; C07H15/256
Attorney, Agent or Firm:
三枝 英二 (外2名)