Title:
ムスカリン性アセチルコリンレセプターＭ４のポジティブアロステリック調節因子
Document Type and Number:
Japanese Patent JP7097623
Kind Code:
B2
Abstract:
Disclosed herein are thieno[2,3-b:5,4-c′]dipyridin-8-amine and pyrido[4′,3′:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Inventors:
Linsley, Craig, W.
Corn, pea., jeffrey
Engers, Darren, W.
Goagro, Allison, Earl.
Temple, Kaira
Sparing, Paul, Kay.
Long, Madeline, F.
Engers, Julie, Elle.
Corn, pea., jeffrey
Engers, Darren, W.
Goagro, Allison, Earl.
Temple, Kaira
Sparing, Paul, Kay.
Long, Madeline, F.
Engers, Julie, Elle.
Application Number:
JP2019522693A
Publication Date:
July 08, 2022
Filing Date:
November 07, 2017
Export Citation:
Assignee:
Vanderbilt University
International Classes:
C07D495/14; A61K31/4375; A61K31/5025; A61K31/506; A61K31/5377; A61K45/00; A61P21/02; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/28; A61P43/00; C07D519/00
Domestic Patent References:
| JP2007508323A |
Foreign References:
| WO2013040534A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki
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