To safely produce the subject powder without using an organic solvent, at a low cost, having improved releasing properties of a hardly soluble material and useful for medicines, cosmetics, etc., by burying the hardly soluble material in starch and thereafter applying a dynamic stress thereon.
The objective powder holding a hardly soluble material in modified porous starch granules is obtained by burying a hardly soluble material (e.g. indomethacin) in a porous starch obtained by acting an enzyme having raw starch- degrading ability (e.g. amylase) on the starch (e.g. corn starch), and thereafter applying a dynamic stress thereon. The application of the dynamic stress is performed by using not only a ball mill, a hammer mill and a vibrating mill but also a jet mil, etc. In the case of the ball mil, the powder holding the hardly soluble material in the modified starch is obtained by changing the structure of the porous starch into an α-structure while enclosing the hardly soluble material therein by impact because the porous starch has viscoelasticity, and in the case of the jet mill, the powder of the modified starch with the attached hardly soluble material is obtained by finely milling the porous starch carrying the hardly soluble material together with the hardly soluble material.
HASEGAWA NOBUHIRO
SUZUKI KAZUMASA
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