PURPOSE: To provide a granulocyte colony-stimulating factor (G-CSF)-containing transnasal powdery preparation which contains G-CSF and saccharides and can allow the patients to safely absorb G-CSF through the nasal mucosa efficiently, thus is effective for treating dyshematopiosia or a chemical therapy or radioactive therapy therefor and on bone marrow transplantation.

CONSTITUTION: This pharmaceutical preparation comprises (A)G-CSF (for example, a polypeptide having the amino acid sequence of the formula and a human G-CSF activity, or a glycoprotein having a saccharide chain linked to the polypeptide, (B) a saccharide such as mannitol, lactose or the like, further, when needed, (C) a carboxyvinyl polymer, polyvinyl pyrrolidone, a agar powder, arabic gum, gelatin, hyaluronic acid or a salt thereof, hydroxypropyl cellulose or crystalline cellulose and can be transnasally given in a dose of 1-5,00, particularly 5-100μg/kg body weight/day of the component (A).