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Title:
PREGNANE STEROID FOR USE IN TREATMENT OF CNS DISORDER
Document Type and Number:
Japanese Patent JP2010065052
Kind Code:
A
Abstract:

To identify new specific blockers of 3-hydroxy-pregnan-steroid, and to provide new therapeutic substances relating to the steroid and/or derived from the steroid, for treatment, amelioration or prevention of CNS (Central Nervous System) disorder.

Steroid compounds possessing a hydrogen donor in 3 position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for steroid-related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of CNS disorders induced by many specific steroids.


Inventors:
TORBJOERN BAECKSTROEM
PER LUNDGREN
WANG MING-DE
JOHANSSON INGA-MA
Application Number:
JP2009256620A
Publication Date:
March 25, 2010
Filing Date:
November 10, 2009
Export Citation:
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Assignee:
UMECRINE COGNITION AB
International Classes:
A61K31/57; A61K45/00; A61K31/56; A61K31/573; A61P3/04; A61P5/28; A61P5/30; A61P15/08; A61P15/16; A61P15/18; A61P25/00; A61P25/02; A61P25/06; A61P25/08; A61P25/20; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07J5/00
Other References:
JPN6012030078; FEUER,G. et al: 'Differential action of progesterones on hepatic microsomal activities in the rat' Biochem Pharmacol Vol.26, No.16, 1977, p.1495-9
JPN7012002211; EDWARDS,A.M. et al: 'Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids' J Biol Chem Vol.250, No.7, 1975, p.2750-5
JPN7012002212; BOWEN,C.A. et al: 'Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol t' J Pharmacol Exp Ther Vol.289, No.1, 1999, p.405-11
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito