To identify new specific blockers of 3-hydroxy-pregnan-steroid, and to provide new therapeutic substances relating to the steroid and/or derived from the steroid, for treatment, amelioration or prevention of CNS (Central Nervous System) disorder.
Steroid compounds possessing a hydrogen donor in 3 position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for steroid-related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of CNS disorders induced by many specific steroids.
PER LUNDGREN
WANG MING-DE
JOHANSSON INGA-MA
JPN7012002211; EDWARDS,A.M. et al: 'Induction of delta-aminolevulinic acid synthetase in isolated rat liver cells by steroids' J Biol Chem Vol.250, No.7, 1975, p.2750-5
JPN7012002212; BOWEN,C.A. et al: 'Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol t' J Pharmacol Exp Ther Vol.289, No.1, 1999, p.405-11
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
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