Title:
1,3,5-トリアミノベンゼンの調製とそれを高純度のフロログルシノ-ルに加水分解する方法
Document Type and Number:
Japanese Patent JP2005534659
Kind Code:
A
Abstract:
Preparing 1,3,5-triamino benzene comprises amination of a halobenzene (I) in the presence of ammonia and a catalyst selected from copper salts, cuprous and cupric oxides, and their mixtures, at a temperature of 150 - 250degreesC and a pressure above 35 bars. Preparing 1,3,5-triamino benzene comprises amination of a halobenzene of formula (I) in the presence of ammonia and a catalyst selected from copper salts, cuprous and cupric oxides, and their mixtures, at a temperature of 150 - 250degreesC and a pressure above 35 bars. A = halogen or NH2; X1, X2 = halogen. Independent claims are included for: (a) preparing phloroglucinol from 1,3,5-triamino benzene prepared as above, comprising hydrolysis in the presence of HCl or H2SO4 above 90degreesC for 6 - 24 hours, optionally filtering the reaction mixture at ambient temperature, and extracting the phloroglucinol formed using diethyl ether or an ester, especially ethyl benzoate, ethyl acetate, isopropyl acetate, or n-butyl acetate; (b) phloroglucinol prepared by this process containing less than 0.5 % impurities; and (c) the medicinal use of phloroglucinol prepared as in (b).
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Inventors:
Ismaili Lasanne
Le Fevre Bernard
Sicilna Alan
Le Fevre Bernard
Sicilna Alan
Application Number:
JP2004511264A
Publication Date:
November 17, 2005
Filing Date:
June 06, 2003
Export Citation:
Assignee:
Pashve Analytic
International Classes:
A61P21/02; A61K31/05; A61P21/00; A61P25/04; A61P25/08; C07B61/00; C07C29/10; C07C37/05; C07C37/72; C07C37/82; C07C37/84; C07C39/10; C07C209/10; C07C211/49; C07C211/50; C07D209/10; (IPC1-7): C07C39/10; A61K31/05; A61P21/02; A61P25/04; C07C37/05; C07C37/72; C07C37/82; C07C37/84; C07C209/10; C07C211/50
Attorney, Agent or Firm:
Katsunori Sugimoto