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Title:
PREPARATION OF (+)-2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID AND ITS INTERMEDIATE
Document Type and Number:
Japanese Patent JPS5536429
Kind Code:
A
Abstract:

PURPOSE: To prepare the title compound useful as an antiinflammatory agent, an analgesic agent and an antipyretic agent, under mild conditions, in a short time, in high yield, economically, from an easily available 2-thioxo-4-oxothiazolidine via a novel intermediate.

CONSTITUTION: The objective (+)-2-(6-methoxy-2-naphthyl)-propionic acid is prepared by (1) condensing a compound I with 2-acetyl-6-methoxy-naphthalene by dehydration to obtain a novel compound II, (2) hydrolyzing the compound II to a novel compound III, (3) desulfurizing the compound III to obtain a compound IV, (4) converting the compound IV to a racemic compound V by oxidative decarbonation, (5) optically resolving the racemic compound pref. by treating with L-tyrosine hydrazide or L-α-phenylethylamine in an alcoholic solvent with heating, and cooling the reaction mixture, and (6) decomposing the separated diastereomer salt with a strong acid.


Inventors:
KITA CHITSUKAZU
YAMADA HARUO
Application Number:
JP10996778A
Publication Date:
March 14, 1980
Filing Date:
September 06, 1978
Export Citation:
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Assignee:
HAMARI YAKUHIN KOGYO KK
International Classes:
C07D277/20; C07B31/00; C07B57/00; C07C51/00; C07C51/16; C07C51/373; C07C59/64; C07C59/90; C07C67/00; C07C325/00; C07C325/02; C07D277/16; C07D277/36; (IPC1-7): C07C51/16; C07C59/64; C07C151/00; C07D277/16