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Title:
PREPARATION OF 2-CHLORO-4-FLUOROPHENOL
Document Type and Number:
Japanese Patent JPH0399033
Kind Code:
A
Abstract:

PURPOSE: To mildly prepare the subject compound useful as an intermediate for the preparation of drugs and agricultural chemicals from inexpensive raw materials without any specific device in a high yield by carrying out the chlorination reaction of 4-fluorophenol with chlorine gas or sulfuryl chloride in the presence of water.

CONSTITUTION: 4-Fluorophenol as a raw material is chlorinated with chlorine gas or sulfuryl chloride as a chlorination agent in the presence of water to provide the objective compound. The water is suitably used in a volume capable of dissolving all of generated hydrogen chloride. The amount of the used chlorination agent is preferably 0.8-1.2mol in the case of the chlorine gas and 1.6-2.2mol in the case of the sulfuryl chloride. The reaction temperature is 0-80°C. The reaction may be also carried out in the presence of a phase transfer catalyst such as a quaternary ammonium salt.


Inventors:
HIRAI KENJI
YAMASHITA MITSUO
Application Number:
JP23477489A
Publication Date:
April 24, 1991
Filing Date:
September 12, 1989
Export Citation:
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Assignee:
SAGAMI CHEM RES
International Classes:
C07C37/62; C07C39/27; (IPC1-7): C07C37/62; C07C39/27
Domestic Patent References:
JPS5925344A1984-02-09
JPS5444603A1979-04-09
JPS62221645A1987-09-29
JPS6447728A1989-02-22
JPS60193939A1985-10-02