Title:
PREPARATION OF 2-CHLORO-5-AMINOMETHYL-PYRIDINE
Document Type and Number:
Japanese Patent JP3205648
Kind Code:
B2
Abstract:
PURPOSE: To obtain a compound in a high yield in the presence of ammonia and an anhydrous metal catalyst in a nonpolar aprotic diluent at a specific temperature at the time of executing catalytic hydrogenation of 2-chloro-5-cyano- pyridine.
CONSTITUTION: This 2-chloro-5-aminomethylpyridine of formula II is obtained by reacting 2-chloro-5-cyano-pyridine of formula I in the presence of ammonia and an anhydrous metal catalyst (Raney cobalt is suitable). In this case, catalytic hydrogenation is carried out by hydrogen in a nonpolar aprotic diluent (particularly aromatic hydrocarbon is suitable) at 20 to 150°C particularly 80 to 110°C. The 2-chloro-5-aminomethylpyridine of formula II is useful as an intermediate of a hypotensive agent or an insecticide.
Inventors:
Hans-Joachim Dahl
Application Number:
JP18342993A
Publication Date:
September 04, 2001
Filing Date:
June 30, 1993
Export Citation:
Assignee:
Bayer Actien Gezershyaft
International Classes:
C07B61/00; C07D213/61; C07D213/85; B01J25/00; (IPC1-7): C07D213/61; B01J25/00
Domestic Patent References:
| JP4247069A | ||||
| JP4243867A | ||||
| JP61251663A |
Attorney, Agent or Firm:
Heikichi Odashima