Title:
可逆的に不活性な酸性化プラスミン組成物の調製法
Document Type and Number:
Japanese Patent JP5025868
Kind Code:
B2
Abstract:
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
Inventors:
Christopher
Stenland, Christopher Theei
Kent, Jonathan Day
Connie Eva, Marina N
Bomb Batcha, Joji A
Kutuku, Scott A
Bradley, Rita Tay
Novocatoni, Valerie
Billins, Tanned Bee
Stenland, Christopher Theei
Kent, Jonathan Day
Connie Eva, Marina N
Bomb Batcha, Joji A
Kutuku, Scott A
Bradley, Rita Tay
Novocatoni, Valerie
Billins, Tanned Bee
Application Number:
JP2001538490A
Publication Date:
September 12, 2012
Filing Date:
November 13, 2000
Export Citation:
Assignee:
Grifols Therapeutics,Inc.
International Classes:
C12N9/68; C12N9/99; A61B17/00; A61K9/19; A61K38/48; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/26; A61K47/36; A61K47/42; A61M25/00; A61P7/02; A61P9/10; C12N9/96; A61K38/00
Foreign References:
| GB985498B |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
Patent business corporation Odashima patent office
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
Patent business corporation Odashima patent office