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Title:
PREPARATION OF ANTI-HYPERTENSIVE AGENT
Document Type and Number:
Japanese Patent JPH02209865
Kind Code:
A
Abstract:

PURPOSE: To obtain an antihypertensive agent which is an angiotensin converting enzyme inhibiotor by reacting a compound such as a 3-thiopropionic acid derivative with an amino acid derivative.

CONSTITUTION: A compound of formula I (R1 is H, methyl; R2 is L-proline, L-3,4-dehydroproline, L-3-hydroxyproline, L-thiazolysine-4-carboxylic acid, etc., its imino is imino-bonded to adjacent CO; n is 0, 1; when n is O, R is methyl, when n is 1 and R1 is methyl, formula II part is D-structure) is reacted with a compound of a formula R-A (R is H, t-butyloxycarbonyl, cyclopentane carbonyl-L-lysyl, L-lysyl, L-arginyl, etc.; A is phenylalanyl, tryptophyl, tyrosyl, glycyl, leucyl, etc., its α-amino group is amide-bonded to R) to obtain a compound of formula III, for example, Nα-[3-(Nα-benzoyl-phenylalanylthio)-2-D- methylpropanol]-L-proline.


Inventors:
RYAN JAMES WALTER
CHUNG ALFRED
Application Number:
JP82089A
Publication Date:
August 21, 1990
Filing Date:
January 05, 1989
Export Citation:
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Assignee:
UNIV MIAMI
International Classes:
A61K31/40; A61K31/401; A61K31/425; A61K31/426; A61K38/05; A61K38/55; A61P5/38; A61P9/00; A61P9/12; C12N9/99; A61P43/00; B23K9/133; C07D207/16; C07D277/06; C07K1/02; C07K1/113; C07K5/04; C07K5/06; C07K5/065; C07K5/08; C07K14/81; (IPC1-7): A61K31/40; A61K31/425; A61K37/64; C07D207/16; C07D277/06; C07K1/02; C07K5/06; C07K5/08; C12N9/99
Attorney, Agent or Firm:
Akira Asamura (2 outside)