PURPOSE: To prepare the titled substance, by cultivating a microorganism, belonging to the genus Streptomyces, and having the charcteristics to be identified as Streptomyces mojinensis and the ability to produce an antibiotic, and producing and accumulating a recoverable amount of the antibiotic in the culture.
CONSTITUTION: A microorganism, e.g. Streptomyces mojinensis (FERM-P No. 5467), belonging to the genus Streptomyces, and having the ability to produce an antibiotic of the formula or a variant strain thereof is cultivated in a culture medium used for the conventional cultivation of actinomyces by the submerged spinner culture method to produce a recoverable amount of the antibiotic in the culture, and the antibiotic is then recovered. The recovering step is preferably carried out at a low temperature at about a neutral pH. After removing the microbial cell, the antibiotic is isolated and purified by using an adsorbent, an ion exchanger, the gel filtration method, etc.
Hasegawa, Mamoru
Sato, Tomoyasu
Oka, Tetsuo
Kawamoto, Isao
