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Title:
PREPARATION OF ANTIBIOTIC SUBSTANCE 8U-207
Document Type and Number:
Japanese Patent JP57002693
Kind Code:
A
Abstract:

PURPOSE: To prepare the titled substance, by cultivating a microorganism, belonging to the genus Streptomyces, and having the charcteristics to be identified as Streptomyces mojinensis and the ability to produce an antibiotic, and producing and accumulating a recoverable amount of the antibiotic in the culture.

CONSTITUTION: A microorganism, e.g. Streptomyces mojinensis (FERM-P No. 5467), belonging to the genus Streptomyces, and having the ability to produce an antibiotic of the formula or a variant strain thereof is cultivated in a culture medium used for the conventional cultivation of actinomyces by the submerged spinner culture method to produce a recoverable amount of the antibiotic in the culture, and the antibiotic is then recovered. The recovering step is preferably carried out at a low temperature at about a neutral pH. After removing the microbial cell, the antibiotic is isolated and purified by using an adsorbent, an ion exchanger, the gel filtration method, etc.


Inventors:
Furuya, Akira
Hasegawa, Mamoru
Sato, Tomoyasu
Oka, Tetsuo
Kawamoto, Isao
Application Number:
JP1980000076810
Publication Date:
January 08, 1982
Filing Date:
June 06, 1980
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO CO LTD
International Classes:
C12P17/18; A61K31/40; A61P31/04; C12R1/465; C12P17/18; A61K31/40; A61P31/00; (IPC1-7): C12P17/18