Title:
PREPARATION OF BENZYLPENICILLIN DERIVATIVE OR ITS SALT
Document Type and Number:
Japanese Patent JPS5640689
Kind Code:
A
Abstract:
PURPOSE: To prepare the titled compound useful as an antibacterial agent, by reacting an α-aminobenzylpenicillin with a benzoyl isocyanate or a benzoylcarbamic acid halide.
CONSTITUTION: The titled compound of formula IV (R11 is lower alkyl; R2 is H or OH; R3 are 2W3 lower alkanoyloxy groups, at least two of which are adjacent) can be prepared by reacting a compound of formula I or its reactive derivative with a compound of formula II or formula III (X is halogen) in a solvent such as dichloromethane at -30W35°C, pref. -10W20°C. The compound of formula IV thus prepared is an excellent antibacterial agent easpecially effective to the bacteria belonging to Pseudomonas genus.
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Inventors:
OOI NOBUHIRO
AOKI BUNYA
SHINOZAKI TEIZOU
MORO KANJI
MATSUNAGA ISAO
NOFUJI TAKAO
NEHASHI TOSHIYUKI
HARADA YUUSUKE
ENDOU HISAO
KIMURA TAKAO
OKAZAKI HIROSHI
OGAWA HARUKI
SHINDOU MINORU
AOKI BUNYA
SHINOZAKI TEIZOU
MORO KANJI
MATSUNAGA ISAO
NOFUJI TAKAO
NEHASHI TOSHIYUKI
HARADA YUUSUKE
ENDOU HISAO
KIMURA TAKAO
OKAZAKI HIROSHI
OGAWA HARUKI
SHINDOU MINORU
Application Number:
JP11611079A
Publication Date:
April 16, 1981
Filing Date:
September 12, 1979
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07D499/68; A61K31/43; A61P31/04; C07D499/64; (IPC1-7): A61K31/43; C07D499/68
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