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Title:
PREPARATION OF BENZYLPENICILLIN DERIVATIVE OR ITS SALT
Document Type and Number:
Japanese Patent JPS5640689
Kind Code:
A
Abstract:

PURPOSE: To prepare the titled compound useful as an antibacterial agent, by reacting an α-aminobenzylpenicillin with a benzoyl isocyanate or a benzoylcarbamic acid halide.

CONSTITUTION: The titled compound of formula IV (R11 is lower alkyl; R2 is H or OH; R3 are 2W3 lower alkanoyloxy groups, at least two of which are adjacent) can be prepared by reacting a compound of formula I or its reactive derivative with a compound of formula II or formula III (X is halogen) in a solvent such as dichloromethane at -30W35°C, pref. -10W20°C. The compound of formula IV thus prepared is an excellent antibacterial agent easpecially effective to the bacteria belonging to Pseudomonas genus.


Inventors:
OOI NOBUHIRO
AOKI BUNYA
SHINOZAKI TEIZOU
MORO KANJI
MATSUNAGA ISAO
NOFUJI TAKAO
NEHASHI TOSHIYUKI
HARADA YUUSUKE
ENDOU HISAO
KIMURA TAKAO
OKAZAKI HIROSHI
OGAWA HARUKI
SHINDOU MINORU
Application Number:
JP11611079A
Publication Date:
April 16, 1981
Filing Date:
September 12, 1979
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07D499/68; A61K31/43; A61P31/04; C07D499/64; (IPC1-7): A61K31/43; C07D499/68