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Title:
PREPARATION OF ENAMINE IN AQUEOUS MEDIA
Document Type and Number:
Japanese Patent JPH0820577
Kind Code:
A
Abstract:

PURPOSE: To provide a method for economically and safely preparing a highly pure enamine in high yield by condensing a cycloalkanone or a cycloalkanedione with aniline in an aqueous medium.

CONSTITUTION: (A) A compound of formula I [R is CN, CO2H, CO2R1 (R1 is a lower alkyl); X is H, a lower alkyl, a lower alkoxy, a halogen, hydroxy or the like] is condensed with (B) a compound of formula II [Y is CH2 or C=O; (n) is 0, 1 or 2] in the presence of an acidic promoter in an aqueous medium preferably by adding an auxiliary solvent such as ethanol and 2- propanol to provide a compound of formula III in the method for preparing an enamine. Memory enhancing 9-amino-1,2,3,4-tetrahydroacridine can be obtained by cyclizing the compound of the formula III.


Inventors:
YURUGEN MIYURAA REEHARU
Application Number:
JP18654493A
Publication Date:
January 23, 1996
Filing Date:
July 29, 1993
Export Citation:
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Assignee:
HOECHST CELANESE CORP
International Classes:
C07C229/56; C07C233/43; C07C253/30; C07C255/58; C07C255/60; C07D219/10; (IPC1-7): C07D219/10; C07C229/56; C07C233/43; C07C255/58; C07C255/60
Domestic Patent References:
JPH02167267A1990-06-27
Attorney, Agent or Firm:
Chika Takagi (2 outside)