PURPOSE: To prepare a fluorine-containing alcohol, easily, in high yield, by treating a fluorine-containing carbonyl compound with microorganisms.
CONSTITUTION: A fluorine-containing carbonyl compound of formula I [Rf is fluorine-containing aliphatic group, fluorine-containing oxoaliphatic group, or fluorine-containing aromatic group; R is (substituted) aliphatic group] [e.g. CF3(CF2)2-COCH3, etc.] is treated with microorganisms (e.g. baker's yeast) to obtain the fluorine-containing alcohol of formula II (Rf and R are same as defined above) [e.g. CF3(CF2)2CH(OH)CH3, etc.], easily, in high yield. The fluorine-containing alcohol prepared by this process can be used as a solvent as well as a synthetic intermediate of water- and oil-repellent, pharmaceuticals, agricultural chemicals, etc., and is useful also as a raw material of monomer for the preparation of fluorine-containing polymer and raw material of various esters.
KITATSUME TOMOYA