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Patent Searching and Data


Title:
PREPARATION OF GLUCOSE COMPOUND
Document Type and Number:
Japanese Patent JPS58203999
Kind Code:
A
Abstract:

PURPOSE: To prepare a glucose compound useful as a drug, in high yield, by reacting dialkoxymethylbenzene, etc. with D-glucono-δ-lactone, and reducing the resultant 4,6-O-benzylidene-D-glucono-δ-lactone.

CONSTITUTION: The objective 4,6-O-benzylidene-D-glucose is prepared by reacting a compound such as dialkoxymethylbenzylidene of formula (R1 and R2 are lower alkyl or together form lower alkylene) with D-glucono-δ-lactone preferably in a polar aprotic solvent such as dimethylformamide, etc. in the presence of a catalyst such as hydrochloric acid, and reducing the resultant 4,6-O-benzylidene-D- glucono-δ-lactone with a reducing agent such as sodium borohydride, platinum- chromium oxide, etc. under acidic condition.


Inventors:
Sasaki, Kazuya
Hamazaki, Yasuhiko
Yamamoto, Toshiyuki
Application Number:
JP1982000086443
Publication Date:
November 28, 1983
Filing Date:
May 24, 1982
Export Citation:
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Assignee:
KAKEN PHARMACEUT CO LTD
RIKAGAKU KENKYUSHO
KOCHI MUTSUYUKI
International Classes:
C07H9/04; (IPC1-7): C07H9/04