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Patent Searching and Data


Title:
PREPARATION OF N-HYDROXY-ALPHA-AMINO ACID AND ITS DERIVATIVE AND COMPOUND THUS OBTAINED
Document Type and Number:
Japanese Patent JPH021446
Kind Code:
A
Abstract:

PURPOSE: To obtain the compd. with high yield by a method wherein α-amino acid amide is used as a starting substance and a Schiff base is formed with an arom. aldehyde and it is oxidized to oxazilidine.

CONSTITUTION: A compd. of formula I [wherein R1 and R2 are each H, a non- cyclic or cyclic (substd.)alkyl and a (substd.) aryl; the substd. group is not oxidized under the treating condition or it can be protected from the reaction by introducing a protective group) is reacted with an arom. aldehyde pref. in an aqueous medium to form a Schiff base. The Schiff base is oxidized with an org. peroxyacid (e.g. m-chloroperoxy benzoic acid) to obtain oxazilidine and then, it is treated with hydroxylamine hydrochloric acid salt in an alcohol medium to obtain an aimed compd. of formula II.


Inventors:
YOHAN KANPUFUISU
BUIRUHERUMUSU FUUBERUTOUSU YOO
Application Number:
JP1989000024080
Publication Date:
January 05, 1990
Filing Date:
February 03, 1989
Export Citation:
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Assignee:
STAMICARBON
International Classes:
C07C239/18; C07C251/16; C07C291/00; C07D273/01; (IPC1-7): C07C239/18