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Patent Searching and Data


Title:
PREPARATION OF NAPHTHACENEQUINONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS58124736
Kind Code:
A
Abstract:

PURPOSE: To prepare 2-oxo-5,12-dihydroxy-1,2,3,4-tetrahydro-6,11-naphthacenequinone, by acyloxylating and hydrolyzing a 6-hydroxy-5,12-naphthacenequinone derivative.

CONSTITUTION: The objective compound of formula III can be prepared by (1) acyloxylating the compound of formulaI(one of R1 and R2 is H and the other is lower alkylenedioxy)with an acyloxylating agent[e.g. Pb(OCOCH3)4]in a proper solvent at about room temperature, and (2) hydrolyzing the resultant compound of formula II in a proper solvent (e.g. water, alcohol, ether, etc.) in the presence of an acid (e.g. mineral acid, trifluoroacetic acid, etc.) at room temperature W80°C.

EFFECT: The objective compound can be prepared in high yield and purity with a simple procedure.

USE: A synthetic intermediate of 4-dimethoxydaunomycin useful as a carcinostatic agent.


Inventors:
TAMURA YASUMITSU
WADA AKIMORI
SASHIYOU MANABU
FUKUNAGA KEIKO
KITA YASUYUKI
Application Number:
JP464882A
Publication Date:
July 25, 1983
Filing Date:
January 14, 1982
Export Citation:
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Assignee:
TAMURA YASUMITSU
International Classes:
C07C46/00; C07C45/00; C07C45/67; C07C50/38; C07C67/00; (IPC1-7): C07C46/00; C07C50/38
Attorney, Agent or Firm:
Eiji Saegusa (1 person outside)