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Title:
PREPARATION OF OPTICALLY ACTIVE PHENYLSERINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS6185380
Kind Code:
A
Abstract:

PURPOSE: To carry out the optical resolution of a mixture of the D- and L- isomers of threo-3-(3,4-methylenedioxyphenyl)serine ester derivative, by using an optically active compound available easily from the antipode of the desired optically active compound, as a resolving agent.

CONSTITUTION: The optically active isomer of the phenylserine derivative of formula I can be prepared by carrying out the optical resolution of a mixture of D-isomer and L-isomer (preferably racemic compound) of the ester derivative of threo-3-(3,4-methylenedioxy-phenyl)serine of formula I (R1 is lower alkyl) using D- or L- threo-N-acyl-3-(3,4-methylenephenyl)serine derivative of formula II (R2 is H or alkyl) as an optical resolution agent, and desalting the obtained carboxylic acid salt of an optically active phenylserine ester derivative.

USE: In intermediate of the compound of formula III useful as a remedy for peripheral orthostatic hypotension, antidepresent, remedy for Parkinson's disease, etc.


Inventors:
ISHIZUMI KIKUO
MAEJIMA KAORU
NAGATA SHOJI
KOJIMA YOSHIYUKI
Application Number:
JP20763584A
Publication Date:
April 30, 1986
Filing Date:
October 02, 1984
Export Citation:
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Assignee:
SUMITOMO PHARMA
International Classes:
C07B57/00; C07B31/00; C07C67/00; C07D317/60; (IPC1-7): C07B57/00; C07D317/60