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Title:
PREPARATION OF PENICILLANIC ACID DERIVATIVE OR ITS SALT
Document Type and Number:
Japanese Patent JP56040687
Kind Code:
A
Abstract:

NEW MATERIAL:A penicillanic acid derivative of formula I (R1 is H or lower alkyl; R2 is H or OH; R3 are 2W3 OH or lower alkanoyloxy groups, at least two of which are adjacent; when R1 is lower alkyl and R3 is OH, the substitution position of R3 is 3W5 position, and otherwise, it is 2W6 position.) or its salt, and a substituted ureidophenylacetic acid of formula II.

EXAMPLE: 6-[ D(-)-α-[ 3-( 2,3-dihydroxybenzoyl )-1-ureido ]-α-phenylacetamido ] penicillanic acid.

USE: An antibacterial agent and its intermediate, effective remarkably to the bacteria belonging to Pseudomonas genus.

PROCESS: The compound of formula I can be prepared, e.g. by reacting an α-aminophenyl-acetic acid with a benzoyl isocyanate and further reacting the resulting compound of formula II with 6-aminopenicillanic acid or its reactive derivative.


Inventors:
OI, Nobuhiro
Aoki, Bunya
Shinozaki, Teizo
Moro, Kanji
Matsunaga, Isao
Nofuji, Takao
Nehashi, Toshiyuki
Harada, Yusuke
Endo, Hisao
Kimura, Takao
Okazaki, Hiroshi
Ogawa, Haruki
Shindo, Minoru
Application Number:
JP1979000116108
Publication Date:
April 16, 1981
Filing Date:
September 12, 1979
Export Citation:
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Assignee:
CHUGAI PHARMACEUT CO LTD
International Classes:
C07D499/68; A61K31/43; A61P31/04; C07D499/64; C07D499/00; A61K31/429; A61P31/00; (IPC1-7): A61K31/43; C07D499/68