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Title:
PREPARATION OF PENICILLANIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP56040688
Kind Code:
A
Abstract:

PURPOSE: To prepare a penicillanic acid derivative or its salt useful as an antibacterial agent, by eliminating the protecting group from a specific protected penicillanic acid derivative.

CONSTITUTION: A compound of formula II (R1 is H or lower alkyl; R2 is H or OH; R3 are 2W3 OH groups, at least two of which are adjacent) is obtained by eliminating the protecting group of a compound of formula I (R21 is H or OH which may be protected; R31 are R3 or protected R3; Y is H or carboxy-protecting group; at least one of R21, R31 and Y is protecting group). The protecting group of R21 and R31 is e.g. lower alkanoyl group, which can be eliminated by treating with a base in a solvent in the presence of an alcohol, etc. The protecting group of Y is e.g. trimetylsilyl group, which can be eliminated by treating with water or an alcohol.


Inventors:
OI, Nobuhiro
Aoki, Bunya
Shinozaki, Teizo
Moro, Kanji
Matsunaga, Isao
Nofuji, Takao
Nehashi, Toshiyuki
Harada, Yusuke
Endo, Hisao
Kimura, Takao
Okazaki, Hiroshi
Ogawa, Haruki
Shindo, Minoru
Application Number:
JP1979000116109
Publication Date:
April 16, 1981
Filing Date:
September 12, 1979
Export Citation:
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Assignee:
CHUGAI PHARMACEUT CO LTD
International Classes:
C07D499/68; A61K31/43; A61P31/04; C07D499/64; C07D499/00; A61K31/429; A61P31/00; (IPC1-7): A61K31/43; C07D499/68