Title:
PREPARATION OF RACEMIC AND OPTICALLY ACTIVE 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND ITS PRECURSOR
Document Type and Number:
Japanese Patent JPH04334370
Kind Code:
A
Abstract:
PURPOSE: To obtain the subject optically active compound without formation of by-products by cyclizing a specific compound, then treating with acid after basic hydrolysis of the resulted compound, and allowing the resulted mixture to react in an acid medium.
CONSTITUTION: The compounds of formulae IV, V and VI are obtained by cyclizing the compound of formula I (X is Cl or Br) with the compound of the formula (CO2R1)2CHNHCOR2 [R1 is a 1-4C alkyl; R2 is H, etc.], in a basic medium to obtain the compound of formula II, then hydrolyzing the compound of formula II under the basic conditions, further decarboxylating by acid treatment to obtain the compound of formula III, and allowing the compound of formula III to react in an acid medium.
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Inventors:
BERUNHARUTO KAMAAMAIAA
URURITSUHI RERUHI
URURITSUHI RERUHI
Application Number:
JP982592A
Publication Date:
November 20, 1992
Filing Date:
January 23, 1992
Export Citation:
Assignee:
HOECHST AG
International Classes:
C07D217/26; (IPC1-7): C07D217/26
Attorney, Agent or Firm:
Chika Takagi (2 outside)
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