PURPOSE: To obtain the titled compound useful as an agent for testing pancreatic function, etc., at low temperature, in a short time, in high activity and purity, with simple purification process, without side reactions, by removing the protecting group of a novel heptacosapeptide having a specific structural formula.
CONSTITUTION: Secretin is prepared by removing the protecting group from a heptacosapeptide having a novel structural formula (Boc, His, etc. are abbreviations of tert-butyloxycarbonyl, histidine, etc. which are widely used in the field of peptide chemistry). The removel of the protecting group is preferably carried out in a short time, in one step by treating the compound with a strong acid (e.g. trifluoromethanesulfonic acid, hydrogen fluoride, etc.). The characteristic feature of the compound is the protection of the amino group of the N-terminal and the side chain functional groups of all constituent amino acids of secretin.
SATOU TAKASHI
YOSHINO HIROSHI
TSUCHIYA YUTAKA
KONISHI YUUSUKE
TSUJII MASAHIKO
HISATAKE YOSHIHIKO
KOIWA ATSUSHI
| JPS56158748A | 1981-12-07 | |||
| JPS56158747A | 1981-12-07 | |||
| JPS51113870A | 1976-10-07 |
Next Patent: BIS-N,N'-(3-BENZYLOXY-2-NITRO-4-SUBSTITUTED-BENZOYL) ALKYLDIAMINE DERIVATIVE AND ITS PREPARATION