PURPOSE: To produce a tricyclic compound useful as an synthetic intermediate for producing medicines by a new and simple method.
CONSTITUTION: A compound of formula I [R1 to R3 are H, alkyl, halogen, NO2, CN, CF3, alkoxy, carboxy, CONR5R6 (R5, R6 are H, alkyl, etc.,), etc.; R4 is H, alkyl, etc.,), etc,; R4 is H, alkyl, alkanoyl; Y1 and Y2 are CH2O, CH2CH2, CH=CH, NR10CO (R10 is H, alkyl, benzyl)] is reacted with a compound of formula II [X1 is nitrile, alkyl, group of formula III (R11, R13 are H, alkyl, phenyl, pyridyl, allyloxy, alkoxy, benzyloxy, or R11 and R12, or R11 and R13 from a five to seven membered ring through an alkylene chain)] in the presence of a Lewis acid, protonic acid or acid anhydride to obtain a compound of formula IV (X2 is nitrile, allyl, -CR11R12, -COR13). By the method, a new dibenzooxepine derivative of formula V, e.g. 11-alkyl-6,11-dihydrodibenz[b. e]oxepine-2-carboxylic acid methyl ester is obtained.
KUMAZAWA TOSHIAKI
OBASE HIROYUKI
