Title:
β2-アゴニストの溶液を含有する加圧式定量用量吸入器
Document Type and Number:
Japanese Patent JP2005524664
Kind Code:
A
Abstract:
A pharmaceutical aerosol formulation to be administered by a pressurized metered dose inhaler comprising as active ingredients formoterol fumarate in a concentration comprised between 0.003 and 0.192% w/v and beclometasone dipropionate, in a solution of a liquefied hydrofluoroalkane (HFA) propellant, ethanol in anhydrous form as co-solvent, in a concentration comprised between 10% and 20% w/w, and hydrochloric acid, in a concentration such that the apparent pH range of the formulation is between 2.5 and 5.0, wherein the amount of residual water is less than 1500 ppm on the total weight of the formulation, and wherein the fraction of particles equal or less than 1.1 µm delivered on actuation of the inhaler is at least 30%, for use in the treatment of a respiratory disorder.
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Inventors:
Davies, Rebetska Jeanne
Gunderton, David
Lewis, David Andrew
Meakin, Brian Jiyoung
Tchaia, Tania Kiasleen
Bran Vila, Getano
Fuellaris, Aretz Sandra
Gunderton, David
Lewis, David Andrew
Meakin, Brian Jiyoung
Tchaia, Tania Kiasleen
Bran Vila, Getano
Fuellaris, Aretz Sandra
Application Number:
JP2003572545A
Publication Date:
August 18, 2005
Filing Date:
February 27, 2003
Export Citation:
Assignee:
Chiesi, Falmatie Uteich, Sochieta, Per, Ationi
International Classes:
A61K9/12; A61K9/00; A61K9/72; A61K31/00; A61K31/167; A61K31/4704; A61K31/485; A61K45/06; A61K47/06; A61K47/10; A61P11/00; A61P11/06; A61P11/08; A61P11/16; A61P43/00; C07D215/26; (IPC1-7): A61K31/4704; A61K9/72; A61K47/10; A61K47/34; A61P11/00; A61P11/06; A61P11/16; C07D215/26
Foreign References:
| EP1157689A1 | 2001-11-28 | |||
| EP1449528A1 | 2004-08-25 | |||
| WO2001019342A2 | 2001-03-22 |
Attorney, Agent or Firm:
Heikichi Odashima