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Title:
PREVENTING OR IMPROVING AGENT FOR HYPERTENSION OR MEDICAL SYMPTOM CAUSED THEREBY
Document Type and Number:
Japanese Patent JPH08268887
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject new agent containing adioxabicyclooctane deriva tive having a specific structure as an active ingredient, capable of significantly suppressing the elevation of a blood pressure, and having less adverse effects and a high stability.

CONSTITUTION: This suppressing or improving agent for hypertension or medical symptoms caused thereby contains a dioxabicyclo [3. 3. 0] octane derivative of the formula (R1 to R6 are each H, a 1-3C alkyl, etc.; (n), (m), (l) are each 0, 1) [e.g., sesamin, (2,6-bis-(3-methoxy-4-hydroxypheny)-3,7-dioxabicyclo [3. 3. 0] octane), etc.] as an active ingredient. The compound of the formula is obtained, e.g., by purifying and isolating sesame oil extract material obtained by extracting a sesame oil with an organic solvent such as acetone, with a conventional method such as a column chromatography. Also, it is preferable to administer the compound of the formula with tocopherols for the potentiation of its preventing or improving effect.


Inventors:
Akimoto, Kengo
Morimoto, Shiro
Matsumura, Yasuo
Yoshizumi, Hajime
Murakami, Tetsuo
Application Number:
JP1995000070205
Publication Date:
October 15, 1996
Filing Date:
March 28, 1995
Export Citation:
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Assignee:
SUNTORY LTD
International Classes:
A23C15/12; A23L1/30; A61K31/34; A61K31/357; A61K31/36; A61P9/12; (IPC1-7): A61K31/34; A23C15/12; A23L1/30
Attorney, Agent or Firm:
石田 敬 (外3名)