Title:
PREVENTING AND THERAPEUTIC AGENT FOR VIRAL INFECTIOUS DISEASE
Document Type and Number:
Japanese Patent JPH10101591
Kind Code:
A
Abstract:
To obtain a new benzene derivative, having selective strong antiviral activities against only viruses without affecting a host cell, and useful as a preventing and therapeutic agent for viral diseases (e.g. a hepatitis C virus).
This compound is represented by formula I [A is O, S, NH, CH,, etc.; X and Y are each H or, together, are a single bond, O, S, etc.; R1 to R8 are each H, a group represented by the formula C(U1)R9 (U1 is 0 or S; R9 is H, OH, a halogen, etc.), etc.], its salt or a hydrate thereof, e.g. 2,7-bis[2-(4- morpholino)ethyloxy]fluorenone. A compound, represented by formula II and belonging to the compound represented by formula I is obtained by reacting a compound represented by formula III with a compound represented by formula IV (X is OH or a halogen) in the presence of a base such as sodium hydride.
Inventors:
KAI YASUNOBU
SASHO MANABU
KAKO YUMIKO
TSUKADA ITARU
YANAGISAWA MANABU
Application Number:
JP27719496A
Publication Date:
April 21, 1998
Filing Date:
September 27, 1996
International Classes:
C07D295/08; A61K31/12; A61K31/135; A61K31/34; A61K31/343; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/4025; A61K31/403; A61K31/415; A61K31/435; A61K31/44; A61K31/443; A61K31/445; A61K31/535; A61K31/5375; A61P1/16; A61P31/12; C07C13/547; C07C13/567; C07C39/17; C07C39/23; C07C43/257; C07C49/643; C07C49/784; C07C211/44; C07C211/54; C07C211/57; C07C217/90; C07C217/92; C07C219/34; C07C225/22; C07C323/18; C07D207/48; C07D209/88; C07D219/04; C07D219/06; C07D219/10; C07D307/91; C07D311/86; C07D335/16; C07D405/14; (IPC1-7): C07C13/567; A61K31/12; A61K31/135; A61K31/34; A61K31/35; A61K31/38; A61K31/40; A61K31/415; A61K31/435; A61K31/44; A61K31/445; A61K31/535; C07C13/547; C07C39/17; C07C39/23; C07C43/257; C07C49/643; C07C49/784; C07C211/44; C07C211/54; C07C211/57; C07C217/90; C07C217/92; C07C219/34; C07C225/22; C07C323/18; C07D207/48; C07D209/88; C07D219/04; C07D219/06; C07D219/10; C07D295/08; C07D307/91; C07D311/86; C07D335/16; C07D405/14
