PREVENTION OF AND RECOVERY FROM DRUG-INDUCED OTOTOXICITY

Title:

PREVENTION OF AND RECOVERY FROM DRUG-INDUCED OTOTOXICITY

Document Type and Number:

Japanese Patent JP2018076326

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions administered prior to onset of acoustic trauma, used for preventing hearing loss due to acoustic trauma.SOLUTION: A pharmaceutical composition has a multiparticulate JNK inhibitor or a multiparticulate neurotroph, allows sustained release of the JNK inhibitor or neurotroph into the ear, e.g. by intraperitoneal administration, for at least 5 days after the administration, and includes a gel formulation or a viscous formulation. The JNK inhibitor is SP600125 and neurotroph is IGF-1, preferably.SELECTED DRAWING: Figure 9

Inventors:

FABRICE PIU
YE QI-ANG
LUIS DELLAMARY
CARL LEBEL

Application Number:

JP2017228433A

Publication Date:

May 17, 2018

Filing Date:

November 28, 2017

Export Citation:

Click for automatic bibliography generation Help

Assignee:

OTONOMY INC

International Classes:

A61K45/00; A61K9/06; A61K31/416; A61K31/4439; A61K31/4545; A61K31/506; A61K31/65; A61K38/18; A61K38/30; A61K47/34; A61P27/16; A61P43/00

Foreign References:

US20100016218A1	2010-01-21
WO2009132050A2	2009-10-29

Attorney, Agent or Firm:

Kazuhiro Kiyohara

Previous Patent: A method of manufacturing Viloxazine salt, and its new many forms

Next Patent: Controlled release peptide formulation