To provide preventives or remedies for septicemia caused by microbial infection.

The preventive or remedy (1) for septicemia caused by microbial infection contains a soybean extract or a soybean fermentate as the active ingredient. The preventive or remedy (2) for septicemia caused by microbial infection contains isoflavone as the active ingredient. A food or drink, a drug, or a cosmetic (3) contains the preventive or the remedy as cited in (1) or (2). The preventives or remedies have high activity in inhibiting the abnormal production of TNF-α and are therefore useful in the fields of cosmetics and foods. They are useful for especially a patient with invasive deep mycosis, who is in a physical condition in which he or she is liable to be attacked by septicemia,.