Title:
始原肝幹細胞および近位肝幹細胞
Document Type and Number:
Japanese Patent JP5463271
Kind Code:
B2
Abstract:
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
Inventors:
Lead roller
Moss Nicolas G.
Firth Mark Ei.
Ludlow John W.
Bruce Andrew Tea.
Moss Nicolas G.
Firth Mark Ei.
Ludlow John W.
Bruce Andrew Tea.
Application Number:
JP2010270893A
Publication Date:
April 09, 2014
Filing Date:
December 03, 2010
Export Citation:
Assignee:
University of North Carolina at Chapel Hill
Inkara Cell Technologies, Inc.
Inkara Cell Technologies, Inc.
International Classes:
C12N5/071; A61K35/12; A61K35/407; A61K35/48; A61P1/16; C12N5/074; C12N5/0789; C12N5/10
Domestic Patent References:
| JP2005520513A | ||||
| JP2000287680A |
Foreign References:
| US5576207 |
Other References:
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BERGER,BLOOD.,1998年11月15日,V92 N10,SUPPL.1PART1-2,P567A
LEMMER,JOURNAL OF HEPATOLOGY.,1998年 9月,V29 N3,P450-454
ROSKAMS,JOURNAL OF HEPATOLOGY.,1998年 9月,V29 N3,P455-463
TATENO,WOUND REPAIR AND REGENERATION.,1999年,V7 N1,P36-44
J.Hepatol., vol.29, pp.450-454 (1998)
J.Pathol., vol.188, pp.201-206 (1999)
J.Hepatol., vol.29, pp.455-463 (1998)
BERGER,BLOOD.,1998年11月15日,V92 N10,SUPPL.1PART1-2,P567A
LEMMER,JOURNAL OF HEPATOLOGY.,1998年 9月,V29 N3,P450-454
ROSKAMS,JOURNAL OF HEPATOLOGY.,1998年 9月,V29 N3,P455-463
TATENO,WOUND REPAIR AND REGENERATION.,1999年,V7 N1,P36-44
J.Hepatol., vol.29, pp.450-454 (1998)
J.Pathol., vol.188, pp.201-206 (1999)
J.Hepatol., vol.29, pp.455-463 (1998)
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto