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Title:
PROCESS FOR PREPARATION OF 6-ALPHA,9-ALPHA-DIFLUORO-17-ALPHA-[(2-FURANYLCARBONYL)OXY]-11-BETA-HYDROXY-16-ALPHA-METHYL-3-OXO-ANDROSTA-1,4-DIENE-17-BETA-CARBOTHIOIC ACID S-FLUOROMETHYL
Document Type and Number:
Japanese Patent JP2014177482
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel process for preparing a compound of the formula (I).SOLUTION: A process comprises converting 6-alpha,9-alpha-difluoro-17-alpha-[(2-furanyl carbonyl)oxy]-11-beta-hydroxy-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta-carbothioic acid S-furoyl ester via 6-alpha,9-alpha-difluoro-17-alpha-[(2-furanyl carbonyl)oxy]-11-beta-hydroxy-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta-carbothioic acid or a salt thereof to a compound of the formula (I) without isolating any intermediates.

Inventors:
MALCOLM BRIAN BERRY
MARK JASON HUGHES
DAVID PARRY-JONES
STEPHEN JOHN SKITTRALL
Application Number:
JP2014103872A
Publication Date:
September 25, 2014
Filing Date:
May 20, 2014
Export Citation:
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Assignee:
GLAXO GROUP LTD
International Classes:
C07J17/00
Domestic Patent References:
JP2004505989A
Attorney, Agent or Firm:
Yusuke Hiraki
Setsu Fujita
Arai Eiichi
Natsuo Tanaka