Title:
PROCESS FOR PREPARATION OF FLUTICASONE PROPIONATE FORM 1
Document Type and Number:
Japanese Patent JP2017031161
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph having controlled particle size and being suitable for micronization.SOLUTION: The novel crystallization process comprises the step of dissolving fluticasone propionate in acetone or in a solvent comprising a mixture of acetone and 0-10% water, and then adding this solution to water or to a non-solvent comprising a mixture of water and 0-35% acetone, thereby crystallizing fluticasone propionate out of the solution as a crystalline form.SELECTED DRAWING: Figure 4
Inventors:
MARTYN DAVID TICEHURST
IVAN MARZIANO
ELEFTHERIOS KOUGOULOS
IVAN MARZIANO
ELEFTHERIOS KOUGOULOS
Application Number:
JP2016164301A
Publication Date:
February 09, 2017
Filing Date:
August 25, 2016
Export Citation:
Assignee:
PFIZER LTD
International Classes:
C07J3/00
Domestic Patent References:
| JP2014520848A | 2014-08-25 |
Foreign References:
| WO2001032125A2 | 2001-05-10 | |||
| WO2000038811A1 | 2000-07-06 | |||
| WO2003061816A1 | 2003-07-31 | |||
| WO2004001369A2 | 2003-12-31 | |||
| WO2003066653A2 | 2003-08-14 |
Other References:
STECKEL H. ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 258, JPN6015032629, 2003, pages 65 - 75, ISSN: 0003669282
MURNANE D. ET AL., CRYSTAL GROWTH & DESIGN, vol. 8, no. 8, JPN6015032631, 2008, pages 2753 - 64, ISSN: 0003669283
医薬審発第５６８号, JPN7016001044, 1 May 2001 (2001-05-01), ISSN: 0003669284
平山令明, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6015026565, 25 July 2008 (2008-07-25), JP, pages 59 - 60, ISSN: 0003669285
第十六改正 日本薬局方, JPN6014035187, 2011, pages 64 - 68, ISSN: 0003669286
MURNANE D. ET AL., CRYSTAL GROWTH & DESIGN, vol. 8, no. 8, JPN6015032631, 2008, pages 2753 - 64, ISSN: 0003669283
医薬審発第５６８号, JPN7016001044, 1 May 2001 (2001-05-01), ISSN: 0003669284
平山令明, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6015026565, 25 July 2008 (2008-07-25), JP, pages 59 - 60, ISSN: 0003669285
第十六改正 日本薬局方, JPN6014035187, 2011, pages 64 - 68, ISSN: 0003669286
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya