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Title:
PROCESS FOR PREPARATION OF (S)- OR (R)-4-halo-3-HYDROXYBUTYRATE
Document Type and Number:
Japanese Patent JP2013144685
Kind Code:
A
Abstract:

To provide a process for the preparation of enantiomerically pure (S)- or (R)-4-halo-3-hydroxybutyrates.

A 4-halo-3-hydroxybutyrates shown by formula (S)-I or (R)-I are obtained by asymmetric hydrogenation of a 4-halo-3-oxobutyric acid esters in the presence of a catalyst of a ruthenium complex comprising a chiral ligand. In the formula, R1 is CH2X, CHX2 or CX3 and X independently represents Cl and/or Br; R2 is C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further replaced with one or more C1-4-alkyl groups and/or halogen atoms.


Inventors:
Mettler, Hanspeter
Leroux, Frederic
Application Number:
JP2013000032463
Publication Date:
July 25, 2013
Filing Date:
February 21, 2013
Export Citation:
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Assignee:
LONZA AG
International Classes:
C07C67/31; B01J31/24; B01J37/04; C07B53/00; C07C69/675; C07B57/00; C07B61/00
Domestic Patent References:
JP2002037760A2002-02-06
JP2005504129A2005-02-10
JPH10182678A1998-07-07
Foreign References:
Other References:
JPN6014013788; Adv. Synth. Catal. 343, 2001, 264-267
Attorney, Agent or Firm:
蔵田 昌俊
福原 淑弘
中村 誠
野河 信久
白根 俊郎
峰 隆司
幸長 保次郎
河野 直樹
砂川 克
佐藤 立志
岡田 貴志
堀内 美保子
竹内 将訓