To provide a new process for preparing an imiquimod and to provide a new hydroxylamine and a new hydrazine derivative useful as an intermediate for preparation thereof.
The process for preparation is carried out as follows. 4-Chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline represented by formula (I) is reacted with an amine compound represented by formula (II) NH2-X (II) [wherein, X is an OR group or an NR1R2 group {wherein, R is a hydrogen atom, a 1-6C alkyl group, an aryl-1-4C alkyl group, an aryl group or an SO3H (sufo) group; and R1 and R2 are each independently a hydrogen atom, a 1-6C alkyl group, an aryl-1-4C alkyl group, an aryl group or an SO2R3 group (wherein, R3 is an aryl group)}]. The resultant compound, as necessary, is then reacted with a reducing agent.
PORTA ELEONORA
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata
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