Title:
免疫グロブリン組成物を調製するためのプロセス
Document Type and Number:
Japanese Patent JP7073333
Kind Code:
B2
Abstract:
Described is a process for the preparation of pharmaceutically acceptable immunoglobulin compositions from plasma-derived immunoglobulin fractions which allows the parallel preparation of immunoglobulin compositions enriched in IgG, IgM and IgA. In this process, immunoglobulin contained in Cohn fraction I/II/III or Kistler Nitschmann fraction A+I is resolubilized at conductivities of at least 1 mS/cm, and following removal of contaminating protein the resolubilized immunoglobulin is subjected to anion exchange chromatography to obtain IgG- and IgM/IgA-enriched immunoglobulin compositions. The IgG-enriched immunoglobulin composition is further subjected to treatment with a cation exchange material to obtain an immunoglobulin composition having a reduced properdin content.
Inventors:
Oliver Money
Achim Hannappel
Alexander Mehrenkamp-Lettger
Wolfgang Meller
Dieter Rudnick
Achim Hannappel
Alexander Mehrenkamp-Lettger
Wolfgang Meller
Dieter Rudnick
Application Number:
JP2019504003A
Publication Date:
May 23, 2022
Filing Date:
July 26, 2017
Export Citation:
Assignee:
Biotest AG
International Classes:
C07K16/00; A61K39/395; C07K1/18; C07K1/30
Domestic Patent References:
| JP2014522845A | ||||
| JP2001513576A | ||||
| JP2005500265A | ||||
| JP2002517516A | ||||
| JP2012528190A | ||||
| JP2013527201A | ||||
| JP2005509506A | ||||
| JP2014525417A | ||||
| JP2013531630A | ||||
| JP2000515860A |
Foreign References:
| WO2015136217A1 | ||||
| US20140271669 | ||||
| US20130058961 | ||||
| US4296027 |
Other References:
Tanaka et al.,Brazillian Journal of Medical and Biological research,2000年,vol. 33,p. 27-30
Attorney, Agent or Firm:
Yamato Kento
Michiko Matsutani
Yoko Sakurai
Keiji Sakata
Michiko Matsutani
Yoko Sakurai
Keiji Sakata